BioCentury | Oct 28, 2019

Prolactin inhibition could treat MS

...DISEASE CATEGORY: Autoimmune disease INDICATION: Multiple sclerosis (MS) Inhibition of PRL or ZBTB20, a transcription factor...
...model, Parlodel bromocriptine, which blocks PRL production by agonizing dopamine receptors, or an siRNA targeting ZBTB20...
...NYSE:NVS; SIX:NOVN) and China Medical System Holdings Ltd. (HKEX:867) to treat hyperprolactinemia. TARGET/MARKER/PATHWAY: Prolactin (PRL); zinc finger and BTB domain containing 20 (ZBTB20)...
BioCentury | Apr 4, 2017
Distillery Therapeutics

Hepatic; endocrine / metabolic

...INDICATION: Hepatic; diabetes Mouse studies suggest inhibiting ZBTB20 could help treat hepatic steatosis and insulin resistance...
...and testing of liver-specific ZBTB20 inhibitors in models of hepatic steatosis and insulin resistance. TARGET/MARKER/PATHWAY: Zinc finger and BTB domain containing 20 (ZBTB20)...
...CONTACT: Weiping J. Zhang, Second Military Medical University, Shanghai, China email: zbtb20@aliyun.com Hongjiang Li Second Military Medical University Zinc finger and BTB domain containing 20 (ZBTB20)...
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