DISEASE CATEGORY: Musculoskeletal INDICATION: Osteoarthritis Inhibiting the tyrosine protein kinase receptor ROR2 could treat osteoarthritis. Expression levels of the ROR2 ligand WNT5A were higher in human osteoarthritic cartilage than in healthy cartilage. In a mouse fibroblast...

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Diabetes Pancreatic islet-like organoids overexpressing PD-L1 and derived from human induced pluripotent stem cells (iPS cells) could be used to treat Type I diabetes. The organoids were generated by engineering human...

Synthetic switches aim T cells at cells expressing antigen combos David Baker’s team at University of Washington’s Institute for Protein Design published a study in Science showing its synthetic protein switches can direct T cells...

Horizon raising cash after Tepezza beats sales estimate Shares of Horizon Therapeutics plc (NASDAQ:HZNP) rose 24% Wednesday, adding nearly $2.9 billion to the company’s market cap after a 2Q20 earnings report that showed that sales...

Illumina launches U.K. accelerator campus Illumina Inc. (NASDAQ:ILMN) selected three companies to join the first cohort of its new Cambridge, U.K.-based accelerator, and four genomics start-ups for the eleventh funding cycle at its San Francisco...

While the late-stage programs for hearing loss are designed to protect cells in the inner ear, or help them recover from trauma, a growing number of early-stage therapies is aiming for a more dramatic outcome...

As the first disease-modifying therapies for osteoarthritis enter late-stage development, companies are testing new endpoints that can capture effects on joint structure instead of relying on traditional pain-related readouts. Most are converging on MRI imaging...

Fresh off the approval of tislelizumab in China, BeiGene has partnered with Leap to pair the PD-1 inhibitor with the latter’s DKK1 inhibitor to create a combination therapy that could help treat cancers that don’t...

New biological insights and increased recognition from FDA are transforming osteoarthritis from a testing ground for new pain therapies into its own high-priority indication. At least two mechanisms with disease-modifying potential for osteoarthritis (OA) have...

DISEASE CATEGORY: Gastrointestinal INDICATION: Gastrointestinal Increasing WNT signaling through NOTUM inhibition or WNT3A supplementation could promote the regeneration of aged or damaged intestinal epithelia. Expression levels of the extracellular WNT inhibitor NOTUM were higher in...