BioCentury | Jan 17, 2020
Translation in Brief

CPSF3 emerges as new synthetic lethality target in AML and sarcoma

...inhibition and novel DNA damage repair targets, including members of the ATR axis, RAD51 and WEE1...
...Ewing sarcoma breakpoint region 1 PARP - Poly(ADP-ribose) polymerase RAD51 - RAD51 homolog WEE1 - WEE1 tyrosine kinase Inhua...
...early onset (BRCA1) Ataxia telangiectasia and Rad3 related (ATR) (FRP1) Cytidine deaminase (CDA) Poly(ADP-ribose) polymerase (PARP) RAD51 homolog (RAD51) WEE1 tyrosine kinase (WEE1) Cleavage...
BioCentury | Dec 10, 2019
Emerging Company Profile

Zentalis debuts with trio of clinical oncology programs, $85M series C

...as monotherapy in the indication. The biotech has two other clinical programs: ZN-c3, which targets WEE1...
...Radius Health Inc. (NASDAQ:RDUS) and Phase I/II candidate G1T48 from G1 Therapeutics Inc. (NASDAQ:GTHX). AstraZeneca’s WEE1...
...factor receptor 2 WEE1 - WEE1 tyrosine kinase Sandi Wong, Staff Writer Epidermal growth factor receptor (EGFR) (ErbB1) (HER1) WEE1 tyrosine kinase (WEE1) Zentalis...
BioCentury | Aug 17, 2019
Emerging Company Profile

Impact casting a wide synthetic lethality net

...are already four marketed PARP inhibitors. Next in line in Impact’s pipeline is IMP7068, a WEE1...
...Checkpoint kinase 1 DNA-PK - DNA-dependent protein kinase PARP - Poly(ADP-ribose) polymerase WEE1 - WEE1 tyrosine kinase Elizabeth...
...ATM) Breast cancer 1 early onset (BRCA1) Checkpoint kinase 1 (Chk1) (CHEK1) DNA-dependent protein kinase (DNA-PK) Poly(ADP-ribose) polymerase (PARP) WEE1 tyrosine kinase (WEE1) DNA...
BioCentury | Jun 7, 2019
Targets & Mechanisms

Following PARP, ATR axis next in line to expand synthetic lethal drug class

...PARP and BRCA, including the replication stress sensor ATR and its downstream targets Chk1 and WEE1...
...related; Chk1 (CHEK1) - Checkpoint kinase 1; Chk2 (CHEK2) - Checkpoint kinase 2; WEE1 - WEE1 tyrosine kinase...
...Granulocyte macrophage colony-stimulating factor PARP - Poly(ADP-ribose) polymerase PI3K - Phosphoinositide 3-kinase WEE1 - WEE1 tyrosine kinase Karen...
BioCentury | Feb 6, 2018
Distillery Therapeutics

Autoimmune disease

INDICATION: Multiple sclerosis (MS) Cell culture and mouse studies suggest the selective serotonin reuptake inhibitor (SSRI) clomipramine could help treat MS. Screening a library of oral generic drugs that cross the blood-brain barrier (BBB) in...
BioCentury | Jun 9, 2017
Company News

Genomic Vision and AstraZeneca collaborate to screen WEE1 inhibitors

...DNA molecular combing technology from Genomic Vision S.A. (Euronext:GV) to evaluate the impact of WEE1 tyrosine kinase (WEE1...
...Euronext:GV), Bagneux, France AstraZeneca plc (LSE:AZN; NYSE:AZN), London, U.K. Business: Cancer Alicia Parker AstraZeneca plc Genomic Vision S.A. WEE1 tyrosine kinase (WEE1...
BioCentury | Jun 8, 2017
Translation in Brief

Damage potential

...regulators checkpoint kinase 1 (CHK1) and CHK2 , or AZD1775 , an inhibitor of WEE1 tyrosine kinase (WEE1...
...Center Checkpoint kinase 1 (Chk1) (CHEK1) Checkpoint kinase 2 (Chk2) (CHEK2) Mdm2 p53 binding protein homolog (MDM2) (HDM2) WEE1 tyrosine kinase (WEE1) Autoimmune...
BioCentury | May 19, 2016
Distillery Therapeutics

Therapeutics: Chondroitin sulfate proteoglycans (CSPG); versican (VCAN)

Autoimmune disease INDICATION: Multiple sclerosis (MS) In vitro and mouse studies identified a UDP-N-acetylglucosamine-based inhibitor of CSPG synthesis that could help treat MS. Chemical synthesis of UDP-N-acetylglucosamine analogs and testing in mouse and human astrocyte-based...
BioCentury | Dec 3, 2015
Distillery Therapeutics

Therapeutics: Interleukin-1 receptor-associated kinase 1 (IRAK1)

Cancer INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest inhibiting IRAK1 could help treat triple-negative breast cancer (TNBC). IRAK1 levels were higher in tumor samples from patients with aggressive TNBC than from...
BioCentury | Jun 1, 2015
Clinical News

AZD1775: Phase II data

...Whitehouse Station, N.J. Product: AZD1775 , MK-1775 Business: Cancer Molecular target: WEE1 tyrosine kinase (WEE1) Description: WEE1 tyrosine kinase (WEE1...
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