DISEASE CATEGORY: Autoimmune INDICATION: Autoimmune Gene editing of mutated WASp in hematopoietic stem and progenitor cells (HSPCs) could treat Wiskott-Aldrich syndrome. The therapy uses an adeno-associated virus serotype 6 (AAV6) vector to deliver a CRISPR-Cas9...

CSL aims to leverage the logistics expertise it built through its plasma business to expand into cell and gene therapy. The company has a sickle cell disease program in Phase I and is lining up...

INDICATION: Staphylococcus Cell culture and mouse studies suggest the MRGPRX2 activator mastoparan could help treat Staphylococcus aureus skin infection. In cell-based gene reporter assays, the wasp venom toxin mastoparan activated MRGPRX2-mediated phosphorylation of PLC1, which...

Massachusetts Institute of Technology researchers led by Timothy Lu have developed a rational-design method for engineering antimicrobial peptides from toxic molecules such as wasp venom, publishing their third approach to developing AMPs this year and...

INDICATION: Esherichia; Pseudomonas; Staphylococcus Mouse studies identified an analog of the wasp-derived peptide polybia-CP that could help treat E. coli , Pseudomonas and Staphylococcus infections. Chemical synthesis and screening in bacterial colony-based assays of polybia-CP analogs...

INDICATION: Allergy Cell culture studies suggest a CD23-mimicking single-domain antibody against IgE could help treat allergy. The single-domain neutralizing antibody mimics CD23, the low-affinity Fc receptor for IgE, to bind IgE with a K d...

The U.K.'s NICE issued final guidance recommending ALK-Abello's Pharmalgen to treat IgE-mediated bee and wasp venom allergy. The product is recommended for those who have had a severe systemic reaction to bee or wasp venom...