BioCentury | Jun 5, 2019
Company News

June 5 Company Quick Takes: Enzyvant's athymia candidate gets Priority review; plus Alnylam, Corbin and Institute Pasteur

...in-licenses USP15 inhibitors to treat MS Corbin Therapeutics Inc. (Montreal, Quebec) licensed multiple small molecule USP15...
...of a tetravalent vaccine to prevent norovirus infections. Targets: ALAS-1 - Aminolevulinate synthase-1; USP15 - Ubiquitin specific peptidase 15 Elizabeth...
...ALN-AS1) RVT-802 Alnylam Pharmaceuticals Inc. Corbin Therapeutics Inc. Enzyvant Sciences GmbH Institut Pasteur of Shanghai Chinese Academy of Sciences University of Dundee Ubiquitin specific peptidase 15 (USP15)...
BioCentury | Apr 3, 2018
Distillery Therapeutics

Cancer

...INDICATION: Ovarian cancer Cell culture studies suggest inhibiting USP15 could help treat ovarian cancers harboring the...
...mutation in p53. In a p53 R175H-mutant human ovarian cancer cell line, siRNA knockdown of USP15...
...Next steps include evaluating USP15 inhibition in additional models of p53 R175H-mutant ovarian cancer. TARGET/MARKER/PATHWAY: Ubiquitin specific peptidase 15 (USP15)...
BioCentury | Mar 29, 2018
Preclinical News

USP15 a potential ovarian cancer target

...at Baylor College of Medicine and University of Texas MD Anderson Cancer Center suggests inhibiting ubiquitin specific peptidase 15...
...reduced R175H-mutant p53 protein levels compared with normal USP15 expression in both lines, suggesting that USP15...
...Dundee (Dundee, U.K.) in separate deals to discover USP15 inhibitors. At the time, Corbin said USP15...
BioCentury | Jun 1, 2017
Company News

Corbin partners with Proteorex and U of Dundee to identify USP15 inhibitors

...of Dundee (Dundee, U.K.) in separate deals to discover inhibitors of ubiquitin specific peptidase 15 (USP15) . Corbin said USP15...
...MS). Proteorex will use its chemistry platform to discover small molecule peptide conjugates that inhibit USP15...
...jointly. In January, Corbin spun out of AmorChem L.P. (Montreal, Quebec) and received rights to USP15...
BioCentury | Mar 8, 2012
Distillery Therapeutics

Indication: Cancer

...cancer Ubiquitin specific peptidase 15 (USP15); transforming growth factor-b receptor 1 (TGFBR1; ALK5) Studies in patient samples suggest inhibiting USP15...
...TGFB; TGFb) signaling. In glioblastoma samples, USP15 expression was positively correlated with TGFBR1 levels and USP15...
...a negative prognosis. In mice injected with patient-derived glioblastoma neurospheres, small hairpin RNA knockdown of USP15...
BioCentury | Mar 8, 2012
Distillery Therapeutics

Indication: Autoimmune Disease

...cancer Ubiquitin specific peptidase 15 (USP15); transforming growth factor-b receptor 1 (TGFBR1; ALK5) Studies in patient samples suggest inhibiting USP15...
...TGFB; TGFb) signaling. In glioblastoma samples, USP15 expression was positively correlated with TGFBR1 levels and USP15...
...a negative prognosis. In mice injected with patient-derived glioblastoma neurospheres, small hairpin RNA knockdown of USP15...
Items per page:
1 - 6 of 6