BioCentury | Feb 5, 2019
Distillery Therapeutics

Cancer

...the USP7 inhibitors in mouse models of HCC. Hybrigenics S.A. has HBX 19,818, a dual USP7/USP10...
BioCentury | Nov 2, 2017
Targets & Mechanisms

Golden State of DUBs

...Preclinical Progenra Inc. USP7 inhibitor USP7 Cancer Preclinical Hybrigenics S.A. (Euronext:ALHYG) HBX 19,818 USP7 and ubiquitin specific peptidase 10 (USP10)...
...of four other DUBs: Cezanne-1 for inflammation, UCHL1 for fibrosis, USP21 /USP25 for immuno-oncology, and USP10...
...HDM2) - Mdm2 p53 binding protein homolog UCHL1 - Ubiquitin carboxylase-terminal esterase L1 USP10 - Ubiquitin specific peptidase 10...
BioCentury | Nov 1, 2017
Translation in Brief

New Therapeutic Targets and Biomarkers: October 2017

...Acute myelogenous leukemia (AML) Ubiquitin specific peptidase 10 (USP10) In vitro , cell culture and mouse studies identified two USP10...
BioCentury | Oct 10, 2017
Distillery Therapeutics

Cancer

...INDICATION: Acute myelogenous leukemia (AML) In vitro , cell culture and mouse studies identified two USP10...
...FLT3 degradation, followed by in vitro testing of hits against a panel of DUBs, identified USP10...
...and identified two compounds -- a chlorotetrahydroacridine analog and a thionitrothiophene analog -- that inhibited USP10...
BioCentury | Oct 5, 2017
Preclinical News

FLT3 degradation via USP10 could treat AML

...paper published in Nature Chemical Biology , researchers at Dana-Farber Cancer Institute and colleagues identified ubiquitin specific peptidase 10 (USP10)...
...myelogenous leukemia. Using a whole-cell phenotypic screen of DUB inhibitors, researchers identified two small molecule USP10...
...Co. Ltd. FMS-like tyrosine kinase 3 (FLT3) (CD135) Stem cell factor (SCF) receptor tyrosine kinase (c-Kit) (KIT) (CD117) Ubiquitin specific peptidase 10 (USP10)...
BioCentury | Oct 27, 2011
Targets & Mechanisms

Taking down autophagy

...showed that spautin-1 inhibited the two deubiquitinating enzymes that regulate the Vps34 complex-ubiquitin specific peptidase 10 (USP10) and USP13. USP10...
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