BioCentury | Aug 15, 2019
Distillery Therapeutics

TMED9 inhibition for mucin 1 kidney disease

...stem (iPS) cells. The TMED9 inhibitor also produced misfolded protein removal from cells expressing mutant UMOD...
...the kidneys. TARGET/MARKER/PATHWAY: Mucin 1 (MUC1; CD227); transmembrane p24 trafficking protein 9 (TMED9); uromodulin (UMOD; THP...
...School, Boston, Mass. email: agreka@broadinstitute.org Claire Quang Broad Institute of MIT and Harvard Mucin 1 (MUC1) (CD227) Rhodopsin (RHO) (OPN2) Uromodulin (UMOD) (THP) Retinitis Renal...
BioCentury | Oct 20, 2017
Clinical News

DSMB backs Athenex's Phase III breast cancer trial of Oraxol

...Inc. ATP-binding cassette sub-family B member 1 (ABCB1) (MDR1) (PGP) (CD243) P glycoprotein Prostate-specific membrane antigen (PSMA) (FOLH1) (GCPII) 68Ga-THP-PSMA Theragnostics...
BioCentury | Oct 19, 2017
Clinical News

Theragnostics reports Phase I data for prostate cancer imaging agent

...Theragnostics Ltd. (Bracknell, U.K.) said PET/CT imaging agent 68Ga-THP-PSMA did not lead to any adverse events...
...in patients with metastatic disease. Theragnostics also said that uptake seen in the prostate on 68Ga-THP-PSMA...
...68Ga-THP-PSMA comprises gallium linked by tris(hydroxypyridinone) (THP) to PSMA. Theragnostics Ltd. , Bracknell, U.K. Product: 68Ga-THP-PSMA...
BioCentury | Apr 28, 2017
Emerging Company Profile

Cutting cravings

...Targets (2015) Yao, L., et. al. "Inhibition of aldehyde dehydrogenase-2 suppresses cocaine seeking by generating THP...
BioCentury | Dec 19, 2013
Distillery Therapeutics

Indication: Various

...Indication Target/marker/pathway Summary Licensing status Publication and contact information Various Hypertension; renal disease Uromodulin (UMOD; THP...
...family 12 potassium-chloride transporter member 1 (SLC12A1; NKCC2) In vitro and mouse studies suggest inhibiting UMOD...
...UMOD promoter region risk allele that is associated with hypertension and chronic kidney disease risk, UMOD...
BioCentury | Jun 7, 2012
Targets & Mechanisms

Casting out myeloma kidney

...block the interaction between tumor-derived immunoglobulin light chain proteins and an abundant urine protein called uromodulin...
...large aggregates of immunoglobulin light chain ( IgLC ) bound to uromodulin ( UMOD ; THP...
...development and is seeking an industry partner. Role of THP One concern is whether blocking THP's...
BioCentury | May 17, 2012
Distillery Therapeutics

Indication: Renal disease

...status Publication and contact information Renal disease Nephropathy Uromodulin (UMOD; THP) Rat studies suggest antagonizing UMOD...
...to UMOD in the kidney leads to nephropathy. In vitro, a cyclic peptide mimicking the UMOD-binding...
BioCentury | Feb 18, 2010
Cover Story

Gut punch to osteoporosis

U.S. and Indian researchers have shown that blocking the production of serotonin in the gut with a tryptophan hydroxylase 1 inhibitor from Lexicon Pharmaceuticals Inc. can increase bone formation to treat or prevent osteoporosis. 1...
BioCentury | Jul 23, 2009
Tools & Techniques

Knocking out the target in rats

...got the idea for using ZFNs at his previous company, antibody developer THP Inc. "At THP...
...Sangamo and started negotiating a deal." But in 2007, before a deal could be signed, THP's...
BioCentury | Jul 20, 2009
Clinical News

Dara BioSciences preclinical data

...rodent skeletal muscle lines and increased apolipoprotein A-1 ( APOA1 )-specific cholesterol transport in human THP-1...
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