BioCentury | Nov 2, 2017
Targets & Mechanisms

Golden State of DUBs

...UCHL1 inhibitors Ubiquitin C-terminal hydrolase 1 (UCHL1) Liver fibrosis Preclinical Mission Therapeutics Ltd. USP30 inhibitors Ubiquitin specific peptidase 30 (USP30)...
...mitochondrial quality control. Mission hopes to begin clinical trials on its USP30 inhibitor in 2019. “USP30...
...10 USP21 - Ubiquitin specific peptidase 21 USP25 - Ubiquitin specific peptidase 25 USP30 - Ubiquitin specific peptidase 30...
BioCentury | Feb 3, 2016
Financial News

Mission Therapeutics raises L60M

...cellular processes for cancer, neurodegeneration and inflammation. The company has preclinical programs targeting ubiquitin specific peptidase 30 ( USP30...
BioCentury | Jul 17, 2014
Cover Story

Fixing mitophagy in Parkinson's disease

...in Nature that identifies another way to target this pathway. The group linked ubiquitin specific peptidase 30 ( USP30...
...treated with a PD-linked mitochondrial toxin, usp30 knockdown improved motor function and survival. "We believe USP30...
...a possible drug discovery effort, Bingol said that the function of USP30 and safety of USP30...
BioCentury | Jun 26, 2014
Distillery Therapeutics

Indication: Neurology

...USP30 could help treat PD. In a mitochondrial degradation assay using cultured human dopaminergic neurons, USP30...
...damaged mitochondria get degraded that is impaired in PD. In the cultured human dopaminergic neurons, USP30-targeting...
...alteration. Next steps include evaluating USP30 inhibition in mammalian models and identifying pharmacodynamic markers of USP30...
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