...patients, USP13 levels were higher in tumor samples than in adjacent normal lung tissue, and USP13...
...lung and ovarian cancer cell lines cultured under hypoxic or oxidative stress conditions, knockout of USP13...
...increased apoptosis compared with normal expression. Also in the cell lines, knockout or knockdown of USP13...

...ovarian cancer, tumor-specific knockdown of USP13 decreased tumor growth. In one of the models, tumor-specific USP13...
...MK-2206 decreased tumor growth compared with either strategy alone. Next steps include identifying and testing USP13...
...and pancreatic cancer, and Phase I testing for melanoma, renal cancer and solid tumors. TARGET/MARKER/PATHWAY: Ubiquitin specific peptidase 13 (USP13)...

...inhibited the two deubiquitinating enzymes that regulate the Vps34 complex-ubiquitin specific peptidase 10 (USP10) and USP13...