BioCentury | Aug 30, 2018
Targets & Mechanisms

Alt-neoantigens

...splicing events were associated with mutations in five genes: the known splicing regulators SF3B1 and U2AF1...
...associated with antigen processing TCR - T cell receptor TPM3 - Tropomyosin 3 U2AF1 - U2 small nuclear RNA auxiliary factor 1 Karen...
BioCentury | Sep 7, 2015
Clinical News

Imetelstat: Additional Phase II data

...response rate was 38% in patients with a splicing factor 3B subunit 1 (SF3B1) or U2 small nuclear RNA auxiliary factor 1 (U2AF1)...
BioCentury | Sep 4, 2015
Clinical News

Geron rises on published Phase II imetelstat data

...four complete responders had splicing factor 3B subunit 1 ( SF3B1 ) or U2 small nuclear RNA auxiliary factor 1 ( U2AF1...
BioCentury | May 28, 2015
Translation in Brief

Monitoring myelodysplasia

...both targets and animal models for drug development. The studies focused on three factors - U2 small nuclear RNA auxiliary factor 1 (U2AF1)...
...pre-RNA to mRNA, a process that is defective in about 60% of MDS cases. Because U2AF1...
...protein translation or ribosomal pathways; and 3 additional biological pathways. The Washington group concluded the U2AF1...
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