BioCentury | May 26, 2020
Distillery Therapeutics

Boosting Tnip3-mediated inhibition of MAP3K7 for non-alcoholic steatohepatitis

...infiltration, liver fibrosis and serum levels of the liver damage markers AST and ALT. TARGET/MARKER/PATHWAY: TNFAIP3...
BioCentury | Jan 4, 2018
Distillery Therapeutics

Hepatic

...INDICATION: Non-alcoholic steatohepatitis (NASH) Patient sample, mouse and monkey studies suggest promoting TNFAIP3 expression could help...
...compared with normal TNFAIP3 expression, and an adeno-associated viral (AAV) serotype 8 (AAV8) vector encoding TNFAIP3...
...promote TNFAIP3 expression in models of NASH. TARGET/MARKER/PATHWAY: Tumor necrosis factor α-induced protein 3 (TNFAIP3; A20...
BioCentury | Oct 10, 2017
Distillery Techniques

Biomarkers

...of ALS patients. DESCRIPTION: SNP on the locus spanning glutathione peroxidase 3 plasma (GPX3) and TNFAIP3...
...Wray, The University of Queensland, Brisbane, Australia email: naomi.wray@uq.edu.au Hongjiang Li University of Queensland Glutathione peroxidase 3 plasma (GPX3) TNFAIP3...
BioCentury | May 16, 2017
Distillery Techniques

Biomarkers

...levels of eight tumor suppressors -- tumor necrosis factor α-induced protein 3 ( TNFAIP3 ; A20...
...cell CLL lymphoma 10 (BCL10) NK3 homeobox 1 (NKX3-1) PR domain containing 1 with ZNF domain (PRDM1) (BLIMP1) Tumor necrosis factor (TNF) alpha-induced protein 3 (TNFAIP3) (A20)...
BioCentury | Aug 4, 2016
Product R&D

Antibiotic wisdom

...B cells 1 STAT5 - Signal transducer and activator of transcription 5 TNIP1 (Abin1) - TNFAIP3...
BioCentury | Oct 9, 2014
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer Tumor necrosis factor a-induced protein 8-like 3 (TNFAIP8L3; TIPE3); phosphoinositide 3-kinase (PI3K) Studies in human samples and mice suggest inhibiting TNFAIP8L3 could help treat...
BioCentury | Aug 7, 2014
Distillery Techniques

Technology: Disease models

...mouse model of RA with myeloid cell-specific deletion of tumor necrosis factor-a-induced protein 3 (Tnfaip3; A20...
...most models do not recapitulate this dependency on inflammasome activity. In mice, myeloid-specific deletion of Tnfaip3...
BioCentury | Jun 9, 2014
Finance

Liberating Labrys

...week. At least three analysts initiated coverage of the stock last week (see "Analyst Picks," A20...
BioCentury | May 12, 2014
Analyst Picks & Changes

Analyst picks & changes

...prostate cancer drug Provenge sipuleucel-T of $68.8M, which were below his expectations (see "EPS Watch," A20...
BioCentury | Mar 24, 2014
Analyst Picks & Changes

Analyst picks & changes

...children and adults with chronic granulomatous disease and severe, malignant osteopetrosis (see "Horizon's Irish Jig," A20...
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