Preclinical publications highlighted in BioCentury’s Distillery this year identified white space target opportunities including untapped E3 ubiquitin ligases, vesicular regulators and ion channels, as...

EMA accepts aducanumab MAA for reviewBiogen Inc. (NASDAQ:BIIB) and Eisai Co. Ltd. (Tokyo:4523) said the EMA accepted for review an MAA for Alzheimer’s disease candidate aducanumab. The anti-amyloid mAb will undergo standard review, putting a...

DISEASE CATEGORY: Neurology INDICATION: Stroke; neurology Disruption of the NMDA receptor-TRPM4 complex could treat ischemic stroke and other neurodegenerative diseases with NMDA receptor involvement. In mouse hippocampal neurons deprived of oxygen and glucose or treated...

With $100 million in series B funding, Goldfinch Bio Inc. aims to move its second kidney disease therapy into the clinic and begin Phase II testing of its lead candidate. Eventide Asset Management led the...

Building on decades of work on a new mechanism, NoNO Inc. is laying the groundwork for an FDA approval in stroke, a notoriously difficult indication that hasn’t seen a new therapy in almost 25 years....

Interest in kidney diseases is mounting among investors, biotechs and pharmas at a rate reminiscent of the liver disease explosion almost a decade ago. The momentum is driven by improvements at both ends of the...

With GSK effectively bowing out of a 2013 build-to-buy deal with Avalon Ventures after delivering just one exit, the VC is seeking to navigate a future for a handful of Phase I-ready programs it created...

ETH Zurich researchers have created a synthetic gene circuit activated by topical menthol to switch on gene expression and protein production in engineered cells. In a July Nature Medicine paper , the team used the circuit...

DISEASE CATEGORY: Endocrine/Metabolic INDICATION: Diabetes Engineered cells with a synthetic gene circuit could treat diabetes. The system comprises implanted HEK cells encoding a synthetic calcium-responsive promoter and the insulin gene. In Type I diabetic mice,...

DISEASE CATEGORY: Cardiovascular; renal INDICATION: Cardiovascular; renal Cell culture and mouse studies identified a trifluoromethylphenyl-based TRPC6 inhibitor that could help treat cardiac and renal fibrosis. High throughput screening of a small molecule library in cell-based...