BioCentury | May 31, 2017
Distillery Therapeutics

Cancer

...TRIB3 - PML interaction could help treat APL. In AML patients, bone marrow levels of TRIB3...
...Lundbeck A/S and Nippon Shinyaku Co. Ltd. market Trisenox to treat APL. TARGET/MARKER/PATHWAY: Tribbles homolog 3 (TRIB3; TRB3...
...Beijing, China email: huzhuowei@imm.ac.cn Hongjiang Li Chinese Academy of Medical Sciences Peking Union Medical College Promyelocytic leukemia (PML) Tribbles homolog 3 (TRIB3) (TRB3...
BioCentury | Oct 17, 2016
Company News

Trinity diagnostic news

Trinity withdrew its 510(k) submission and will begin a strategic review to determine the best use of its Meritas Troponin-I test technology. The company withdrew the application after FDA raised concerns over the device’s operating...
BioCentury | Sep 3, 2015
Distillery Therapeutics

Therapeutics: Tribbles homolog 3 (TRIB3; TRB3)

...Parkinson's disease (PD) In vitro studies suggest inhibiting TRIB3 could help treat PD. Levels of TRIB3...
...rat and mouse brain cells, treatment with α-synuclein ( SNCA ) or PD-inducing toxins increased TRIB3...
...Next steps could include identifying and testing TRIB3 inhibitors in PD models. TARGET/MARKER/PATHWAY: Tribbles homolog 3 (TRIB3; TRB3...
BioCentury | Apr 6, 2015
Financial News

Trinity completes private placement of senior convertible notes

Trinity Biotech plc (NASDAQ:TRIB), Dublin, Ireland Business: Diagnostic Date completed: 2015-04-02 Type: Private placement of senior convertible notes Raised: $100 million Shares outstanding prior: 23.7 million Investor: Institutional investors Note: The unsecured notes bear 4%...
BioCentury | Apr 3, 2015
Financial News

Funding roundup: Raptor, Conatus, Silence, Northwest, Trinity, Egalet

Rare disease play Raptor Pharmaceutical Corp. (NASDAQ:RPTP) raised $85.5 million through the sale of 9.5 million shares at $9 in a follow-on underwritten by Citigroup; Leerink; Cowen; JMP Securities; and Janney Montgomery Scott. The company...
BioCentury | Jan 26, 2015
Clinical News

Syphilis Health Check regulatory update

FDA granted a CLIA waiver to Diagnostics Direct’s Syphilis Health Check test to detect syphilis. The point-of-care test was marketed in the U.S. as a CLIA moderately to highly complex medical device. The qualitative rapid...
BioCentury | Oct 6, 2014
Clinical News

Meritas BNP test regulatory update

Trinity said it received CE Mark approval for its Meritas BNP test for B-type natriuretic peptide (BNP; NPPB ), a marker for heart failure. The point-of-care blood test delivers results in 10 minutes. Trinity will...
BioCentury | Aug 11, 2014
Company News

Immco, Nicox deal

Immco Diagnostics Inc., a part of Trinity Biotech plc (NASDAQ:TRIB, Dublin, Ireland), granted Nicox exclusive rights in North America to commercialize the Sjo diagnostic panel to detect Sjogren’s syndrome, a systemic autoimmune disease that mainly...
BioCentury | Aug 7, 2014
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Prostate cancer Tribbles pseudokinase 1 (TRIB1) Studies in patient samples and mice suggest inhibiting TRIB1 could help treat prostate cancer. In 3D spheroid assays with...
BioCentury | Feb 17, 2014
Clinical News

Meritas Troponin I test regulatory update

Trinity said its Meritas Troponin I point-of-care test received CE Mark approval as an aid in diagnosing myocardial infarction (MI) in the emergency room. The company immediately launched the fluorescence immunoassay for in vitro quantitative...
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