BioCentury | Jun 7, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: May 2018

New Therapeutic Targets and Biomarkers: May 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during May 2018. Therapeutic targets are defined as any protein, gene or other...
BioCentury | May 23, 2018
Distillery Therapeutics

Neurology; musculoskeletal

INDICATION: Amyotrophic lateral sclerosis (ALS); musculoskeletal In vitro , cell culture and fruit fly studies suggest promoting the expression of TNPO1 could help treat ALS caused by FUS mutations and multisystem proteinopathy caused by HNRNPA1 mutations....
BioCentury | Apr 9, 2015
Distillery Therapeutics

Therapeutics: CC chemokine receptor 5 (CCR5; CD195); transportin 3 (TNPO3)

...INDICATION: HIV / AIDS In vitro studies suggest an aptamer-siRNA conjugate that inhibits CCR5 and TNPO3...
...aptamer that bound CCR5 with a Kd of 113 nM fused to an siRNA targeting TNPO3...
...the conjugate's activity against additional HIV strains. TARGET/MARKER/PATHWAY: CC chemokine receptor 5 (CCR5; CD195 ); transportin 3 (TNPO3)...
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