...Musculoskeletal disease Calcium release-activated calcium channel (CRAC); stromal interaction molecule 1 (STIM1); transmembrane protein 142A (ORAI1; TMEM142A; CRACM1...
...p.R304M mutation in STIM1 in two patients with Stormorken syndrome and the p.P2452 mutation in ORAI1...
...cells, expression of the STIM1 mutation caused constitutive activation of CRAC and expression of the ORAI1...

...see "CRACkdown on pancreatitis"). The complex consists of transmembrane protein 142A ( ORAI1 ; TMEM142A ; CRACM1...
...of digestive problems in children with genetically defective CRACM1 protein may suggest that at least CRACM1...
...to acute pancreatitis.CRACs consist of channel subunits such as transmembrane protein 142A ( ORAI1 ; TMEM142A ; CRACM1...

...SK3); transmembrane protein 142A (ORAI1; TMEM142A; CRACM1) Mouse studies suggest inhibiting the interaction between the SK3 and ORAI1...
...and in mouse xenograft models, the lipid ohmline, which inhibits the localization of SK3 and ORAI1...
...cell migration and bone metastasis compared with vehicle. Next steps include determining whether expression of SK3-ORAI1...

...Transmembrane protein 142A (ORAI1; TMEM142A; CRACM1); Stromal interaction molecule-1 (STIM1) In vitro and mouse studies suggest that ORAI1...
...In vitro, inhibition of Ca2+ entry with SKF96365 or small interfering RNA knockdown of either ORAI1...

...activation, developing inhibitors of the complex formed by stromal interaction molecule-1 ( STIM1 ) and ORAI1...
...TPTX, La Jolla, Calif.), has rights to TPTX's patent applications covering uses of STIM1 and ORAI1...
...calcium release-activated calcium ( CRAC ) channel activity. Recent studies have shown that transmembrane protein 142A (ORAI1, TMEM142A...

...fees, milestones and royalties. Separately, CalciMedica received exclusive rights to develop therapeutics against the institute's Orai1...