BioCentury | Nov 7, 2019
Targets & Mechanisms

New cereblon substrates linked to thalidomide teratogenicity

...Guerrini made a similar association with TP63. She said that thalidomide-exposed newborns and individuals with TP63...
...approved drugs in the class all induce TP63 degradation. “If there is no effect on TP63...
...MM. Targets CRBN - Cereblon SALL4 - Spalt like transcription factor 4 TP63 (p63) - Tumor protein p63 Inhua...
BioCentury | Sep 6, 2018
Preclinical News

Salk team reports gene therapy can re-grow skin in cutaneous ulcers

...keratinocytes. After finding four factors that reprogrammed the cells -- an isoform of tumor protein p63 (TP63; p63...
...delivery method for human tissues and ensure the safety of the factors, including potential oncogene TP63...
...a mouse model of acute skin wounds (see "Accelerated Healing" ). Mark Zipkin Salk Institute for Biological Studies Tumor protein p63 (TP63) (p63) v-myc...
BioCentury | Oct 6, 2016
Distillery Therapeutics

Therapeutics: Tumor protein p63 (TP63; p63); dual specificity phosphatase 6 (DUSP6; MKP3)

...Cancer INDICATION: Cancer Patient sample, cell culture and mouse studies suggest inhibiting TP63 or DUSP6 could...
...p53-mutant breast cancer or head and neck squamous cell carcinoma (HNSCC), high tumor expression of TP63...
...and testing TP63 or DUSP6 inhibitors in animal models of p53-mutant cancers. TARGET/MARKER/PATHWAY: Tumor protein p63 (TP63; p63...
BioCentury | Dec 11, 2014
Distillery Therapeutics

Indication: Pulmonary disease

...Summary Licensing status Publication and contact information Pulmonary disease Pulmonary disease Tumor protein 63 (TP63; p63...
...lung damage caused by influenza infection, postinjury proliferation of endogenous distal airway stem cells expressing Tp63...
...prefibrotic lesions and oxygen exchange deficits. Also in the models, intratracheally delivered transplants of the Tp63...
BioCentury | Feb 20, 2014
Distillery Techniques

Technology: Drug platforms

...contact information Drug platforms Inducing multipotent progenitor cells from keratinocytes by depleting the tumor protein p63 (TP63; p63...
BioCentury | Aug 15, 2013
Distillery Therapeutics

Indication: Cancer

...Publication and contact information Cancer Cancer Keratinocyte growth factor receptor (KGFR; FGFR2; CD332); tumor protein p63 (TP63; p63...
...treat squamous cell carcinoma (SCC). In a newly developed mouse model of chemically induced SCC, p63-mediated...
BioCentury | Mar 18, 2013
Company News

AsymmetRx Medical Inc., Biocare, Roche diagnostic news

...a 2007 patent infringement suit alleging Biocare infringed AsymmetRx's patents covering tumor protein p63 ( TP63 ; p63...
...the settlement, Biocare received worldwide rights from Roche's Ventana Medical Systems Inc. unit to distribute p63...
...fields. Biocare also received non-exclusive rights from Ventana to use patents and materials related to p63...
BioCentury | Dec 3, 2009
Distillery Therapeutics

Indication: Cancer

...Tumor protein p63 (TP63; p63); p53 (TP53) Studies in mice suggest that inducing the expression of particular p63...
...treat cancer. In mice injected with tumorigenic, p53-deficient fibroblasts, expression of any of three different p63...
...transactivation domain helped prevent tumor formation. In the same mice, expression of one of the p63...
BioCentury | Oct 1, 2009
Distillery Therapeutics

Indication: Cancer

...ABL; ABL1; c-ABL); tumor protein p63 (TP63; p63) In vitro and mouse studies suggest that inhibiting the ABL-p63...
BioCentury | Mar 2, 2009
Company News

Celerus sales and marketing update

...cytokeratin (high molecular weight), keratin 7 (KRT7) (CK7) , keratin 20 (KRT20) (CK20) , tumor protein p63 (TP63) (p63)...
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