17:03 , Dec 18, 2014 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3)

Cardiovascular INDICATION: HypertensionMouse studies suggest inhibiting PGF could help treat hypertension. In mice, Pgf knockout decreased Ang2-induced hypertension and associated tissue pathology compared with wild-type Pgf expression. In mice, Pgf suppressed Timp3 TARGET/MARKER/PATHWAY: Angiopoietin 2...
08:00 , Mar 6, 2014 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Myocardial infarction (MI) Tissue inhibitor of metalloproteinases 3 (TIMP3) Pig studies suggest recombinant TIMP3-containing, biodegradable hydrogels could help reduce damage following MI. After MI,...
08:00 , Mar 6, 2014 |  BC Innovations  |  Tools & Techniques

Taking TIMP3 to heart

A U.S. team has found a way to harness the cardioprotective activity of tissue inhibitor of metalloproteinases 3 while avoiding its off-target effects by embedding it in a hydrogel for direct injection into the heart....
08:00 , Dec 6, 2012 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Neurology Tissue inhibitor of metalloproteinases 3 (TIMP3) Mouse studies suggest TIMP3 could help treat traumatic brain injury (TBI). In a mouse model of TBI, i.v....
07:00 , Apr 22, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Ophthalmic disease Age-related macular degeneration (AMD) ATP-binding cassette sub-family A member 1 (ABCA1); cholesteryl ester transfer protein (CETP); lipase hepatic (LIPC); lipoprotein lipase (LPL); tissue inhibitor...
08:00 , Jan 7, 2010 |  BC Innovations  |  Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Lung cancer; liver cancer MicroRNA-221 (miR-221); miR-222; phosphatase and tensin homolog deleted on chromosome ten (PTEN; MMAC1; TEP1); tissue inhibitor of metalloproteinases 3 (TIMP3); tumor...