BioCentury | Aug 8, 2019
Tools & Techniques

Checkpoint inhibitors are bringing oncolytic viruses back into the spotlight

...engineered with cell surface deglycosylation to avoid anti-viral immunity and to deliver the toll-like receptor adaptor molecule 1 (TICAM1; TRIF...
BioCentury | Oct 10, 2016
Emerging Company Profile

Pellino play

...difference in the mechanisms is that pellino-1 mediates TLR adaptor molecule 1 ( TICAM1 ; TRIF...
...data on BBT-401 and other data in the literature suggest that stimulation of the relevant TRIF-mediated...
BioCentury | May 5, 2016
Distillery Therapeutics

Therapeutics: Toll-like receptor adaptor molecule 1 (TICAM1; TRIF); toll-like receptor 2 (TLR2); TLR3

...Cancer INDICATION: Solid tumors Mouse studies suggest a TICAM1-expressing, deglycosylated vaccinia virus could help treat solid...
...did not express TICAM1. In mouse models of mammary, colon, lung and renal cancers, the TICAM1-expressing...
...and Phase I/II testing to treat melanoma, colorectal cancer and renal cancer. TARGET/MARKER/PATHWAY: Toll-like receptor adaptor molecule 1 (TICAM1; TRIF...
BioCentury | Sep 12, 2013
Cover Story

TLR4 signaling in allergic asthma

...proteins myeloid differentiation primary response gene 88 ( Myd88 ) and toll-like receptor adaptor molecule 1 ( Ticam1 ; Trif...
BioCentury | May 16, 2013
Cover Story

Eritoran insight for influenza treatment

...TICAM2; TRAM ), myeloid differentiation primary response gene 88 ( MYD88 ) and TICAM1 ( TRIF...
...MYD88 activates NF-kB to induce production of proinflammatory cytokines, whereas TLR4 signaling that occurs through TRIF...
BioCentury | May 8, 2008
Distillery Therapeutics

This Week in Therapeutics

...TLR4); TIR domain containing adapter inducing interferon-b (TRIF) A study in mice suggests that antagonizing TLR4-TRIF...
...and lower cytokine production (p<0.05) after inactivated H5N1 virus challenge. Similar trends were seen in TRIF-deficient...
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