BioCentury | Jan 25, 2020
Targets & Mechanisms

CAR T strategies for cracking the code in solid tumors

...targets for cancers that arise in the organ where they are expressed, such as targeting TSHR...
...cell death 1 PD-L1 (B7-H1; CD274) - Programmed cell death 1 ligand 1 TSHR - Thyroid stimulating hormone receptor Winnie...
BioCentury | Apr 5, 2019
Targets & Mechanisms

Breaking up Hippo to tame proliferation

...in mesothelioma, schwannoma and meningioma; RHOA in head and neck cancer and T cell lymphoma; TSHR...
...A; STK3 (MST2) - Serine/threonine kinase 3; STK4 (MST1) - Serine/threonine kinase 4; TSHR - Thyroid stimulating hormone receptor...
BioCentury | Jul 13, 2017
Targets & Mechanisms

Insider signaling

...trafficking observed in cell culture data on GPCRs such as the β2 adrenergic receptor and TSHR...
...TACR1 (NK1R) - Tachykinin receptor TrkA (NTRK1) - Neurotrophic tyrosine kinase receptor 1 TSHR - Thyroid stimulating hormone receptor...
BioCentury | May 18, 2017
Product R&D

Making cells compute

...IL-22 , and in response corrected the pathogenic state by secreting adiponectin , insulin, a TSHR...
...Interleukin-10 IL-12 - Interleukin-12 IL-22 - Interleukin-22 TNFα - Tumor necrosis factor α TSHR - Thyroid stimulating hormone receptor...
BioCentury | Feb 25, 2016
Distillery Therapeutics

Therapeutics: Thyroid stimulating hormone receptor (TSHR)

...Endocrine/metabolic disease INDICATION: Thyroid disease Mouse studies suggest cells engineered to express a TSHR antagonist could...
...α fused to a DNA binding domain from a yeast transcription factor; and a protein TSHR...
...the presence of high levels of thyroid hormones, the factor activated the expression of the TSHR...
BioCentury | May 18, 2009
Clinical News

Modified recombinant thyroid stimulating hormone: Phase II data

...Corp. (NASDAQ:GENZ), Cambridge, Mass. Product: Modified recombinant thyroid stimulating hormone (TSH) Business: Endocrine Molecular target: Thyroid stimulating hormone receptor (TSHR)...
BioCentury | Jun 21, 2004
Clinical News

Thyrogen thyrotropin alpha cancer data

...New Orleans. Genzyme Corp. (GENZ), Cambridge, Mass. Product: Thyrogen thyrotropin alpha Business: Cancer Molecular target: Thyroid stimulating hormone receptor (TSHR)...
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