BioCentury | Nov 30, 2018
Targets & Mechanisms

Revving up metabolism at ASH 2018

...10 Adenosine receptors 4 Adenosine A2B receptor (ADORA2B) 1 Adenosine kinase 1 Amino acid metabolism Thymidylate synthetase (TYMS)...
BioCentury | Sep 19, 2017
Distillery Techniques

Biomarkers

...Chugai Pharmaceutical Co. Ltd. market Xeloda, an oral prodrug form of 5-fluorouracil (5-FU) that inhibits thymidylate synthetase (TYMS)...
BioCentury | Mar 2, 2017
Clinical News

Pemetrexed RTD regulatory update

...The product is a ready-to-dilute IV formulation of 25 mg/mL pemetrexed, an antifolate that inhibits thymidylate synthase...
...Pemetrexed RTD ( EP-5101 ) Business: Cancer Julian Zhu pemetrexed RTD Eagle Pharmaceuticals Inc. Dihydrofolate reductase (DHFR) Glycinamide ribonucleotide formyltransferase (GARFT) Thymidylate synthase...
BioCentury | Jan 4, 2017
Clinical News

Pemetrexed RTD regulatory update

...with cisplatin. The product is a ready-to-dilute, IV formulation of pemetrexed, an antifolate that inhibits thymidylate synthase...
...N.J. Product: Pemetrexed RTD (EP-5101) Business: Cancer Julian Zhu EP-5101 pemetrexed RTD Eagle Pharmaceuticals Inc. Dihydrofolate reductase (DHFR) Glycinamide ribonucleotide formyltransferase (GARFT) Thymidylate synthase...
BioCentury | Nov 30, 2016
Distillery Therapeutics

Cancer

...Roche and Chugai market Xeloda capecitabine, an oral prodrug form of 5-fluorouracil (5-FU) that inhibits thymidylate synthetase (TYMS)...
BioCentury | Sep 5, 2016
Company News

Eli Lilly sales and marketing update

...is in line with a July final appraisal determination. Alimta is an antifolate that inhibits thymidylate synthase...
BioCentury | Jul 25, 2016
Company News

Eli Lilly sales and marketing update

...final guidance in August (see BioCentury, March 3, 2014). Alimta is an antifolate that inhibits thymidylate synthase...
BioCentury | Jul 21, 2016
Company News

NICE now backs Alimta maintenance therapy

...into NICE's review process (see BioCentury, March 14) . Alimta is an antifolate that inhibits thymidylate synthase...
BioCentury | Apr 7, 2016
Distillery Therapeutics

Therapeutics: Thymidylate synthetase (TYMS)

...markets Tomudex raltitrexed, an injected cytotoxic agent that inhibits TYMS, to treat colorectal cancer. TARGET/MARKER/PATHWAY: Thymidylate synthetase (TYMS)...
BioCentury | Mar 17, 2016
Distillery Techniques

Techniques: Human induced pluripotent stem (iPS) cell-derived models of gliomagenesis for drug screening

...In a screen of 101 approved cancer drugs, Arranon nelarabine, Femara letrozole and the generic thymidylate synthetase (TYMS)...
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