BioCentury | Apr 4, 2018
Translation in Brief

Targeting TSLP

...the progression of breast cancer.” Nature Immunology (2018) Sandi Wong, Staff Writer Thymic stromal lymphopoietin (TSLP) Thymic stromal lymphopoietin receptor (TSLPR) (CRLF2) Breast...
BioCentury | Apr 3, 2018
Distillery Therapeutics

Cancer

...TSLPR knockout increased tumor cell death and decreased metastasis to the lung compared with normal TSLPR...
...and Phase II testing to treat atopic dermatitis. TARGET/MARKER/PATHWAY: Thymic stromal lymphopoietin (TSLP); thymic stromal lymphopoietin receptor (TSLPR; CRLF2...
...CONTACT: Steven Ziegler, Benaroya Research Institute, Seattle, Wash. email: sziegler@benaroyaresearch.org Sandi Wong Thymic stromal lymphopoietin (TSLP) Thymic stromal lymphopoietin receptor (TSLPR) (CRLF2) Breast...
BioCentury | Apr 11, 2017
Distillery Therapeutics

Inflammation

...INDICATION: Allergy Cell culture studies identified two TSLPR - CD127 fusion proteins that could help treat...
...to treat allergic asthma and atopic dermatitis. TARGET/MARKER/PATHWAY: Thymic stromal lymphopoietin (TSLP); TSLP receptor (TSLPR; CRLF2...
...Belgium email: savvas.savvides@ugent.be Hongjiang Li VIB-UGent Center for Inflammation Research Interleukin-7 (IL-7) receptor (CD127) Thymic stromal lymphopoietin (TSLP) Thymic stromal lymphopoietin receptor (TSLPR) (CRLF2...
BioCentury | May 12, 2016
Distillery Therapeutics

Therapeutics: Thymic stromal lymphopoietin (TSLP); interleukin-33 (IL-33; NF-HEV); IL-25 (IL-17E)

...a human antibody that blocks the interaction of TSLP and TSLP receptor ( TSLPR ; CRLF2...
BioCentury | Jul 30, 2012
Clinical News

RG7258: Development discontinued

...target: Thymic stromal lymphopoietin (TSLP) Description: Humanized mAb against thymic stromal lymphopoetin (TSLP) or ( TSLPR...
BioCentury | Jul 27, 2012
Financial News

Roche reports sales for new cancer drugs

...CRTH2 ) antagonist for asthma; RG7258 , a mAb against thymic stromal lymphopoetin receptor ( TSLPR...
BioCentury | Jul 16, 2012
Strategy

Burying Nutley

...Not in clin dev Ph I RG7258 Humanized mAb against thymic stromal lymphopoetin (TSLP) or (TSLPR...
BioCentury | Sep 11, 2008
Distillery Therapeutics

This Week in Therapeutics

...Licensing status Publication and contact information Dermatology Atopic dermatitis Thymic stromal lymphopoietin (TSLP); TSLP receptor (TSLPR...
...or TSLPR could help treat atopic dermatitis. In a mouse model of allergic skin inflammation, TSLPR...
...to produce proinflammatory cytokines IL-4 and IL-13. Intradermal injection of an anti-TSLP mAb in wild-type TSLPR...
BioCentury | Sep 11, 2008
Targets & Mechanisms

Skin-deep Target

...other epithelial cells. It acts by binding a heterodimeric receptor composed of TSLP receptor ( TSLPR...
...of pediatrics at Harvard and chief of immunology at Children's Hospital Boston . In a TSLPR...
...cells from normal mice but not in those from TSLPR-deficient mice, thus suggesting that the TSLPR-TSLP...
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