BioCentury | Jul 18, 2018
Translation in Brief

Playing chicken with metastasis

In a June study published in Nature Communications , a University of Alberta team described an in vivo screen that identified genetic drivers of cancer metastasis, and the university has spun out Entos Pharmaceuticals Inc. to...
BioCentury | May 3, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: April 2018

New Therapeutic Targets and Biomarkers: April 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during April 2018. Therapeutic targets are defined as any protein, gene or other...
BioCentury | Apr 24, 2018
Distillery Therapeutics

Cancer

INDICATION: Esophageal cancer Patient sample and cell culture studies suggest inhibiting TSPAN15 could help treat esophageal squamous cell carcinoma. In 266 patients, high tumor expression of TSPAN15 was associated with metastasis, disease severity and poor...
BioCentury | Dec 8, 2017
Targets & Mechanisms

Epiphenomena at ASH

While it’s no surprise that cell therapy research is dominant in hematology, the emergence of epigenetics as an equally large focus at this year’s ASH meeting is more notable, reinforcing the resurgence of a field...
BioCentury | Dec 10, 2015
Product R&D

Stem and deliver

Exosomes, once considered cellular debris, are gaining a name in cancer as biopsy-free diagnostic agents, and in drug delivery for their ability to enter cells in a targeted manner. Now, Capricor Therapeutics Inc. wants to...
BioCentury | Oct 8, 2015
Distillery Therapeutics

Therapeutics: Tetraspanin 3 (TSPAN3; TM4SF8)

Cancer INDICATION: Acute myelogenous leukemia (AML); chronic myelogenous leukemia (CML) Patient sample, cell culture and mouse studies suggest inhibiting TSPAN3 could help treat AML and CML. TSPAN3 levels were higher in bone marrow samples from...
BioCentury | Mar 18, 2010
Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Ophthalmic disease Familial exudative vitreoretinopathy Tetraspanin 12 (TSPAN12; NET2) Two independent genetic studies suggest that agonizing TSPAN12 could help treat familial exudative vitreoretinopathy. In one of...
BioCentury | Nov 5, 2009
Targets & Mechanisms

Norrin vs. VEGF

Two papers in Cell describe a new signaling pathway that acts upstream of VEGF to control vascular development in the embryonic retina. The pathway is also present in adults, but the question is whether it's...
BioCentury | Nov 5, 2009
Distillery Therapeutics

Indication: Ophthalmic disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Ophthalmic disease Various indications Frizzled homolog 4 (FZD4); tetraspanin 12 (TSPAN12) Studies in mice and in human cell culture suggest that targeting TSPAN12 could help treat...
BioCentury | Apr 10, 2008
Cover Story

Metastasis, Interrupted

Two studies have clarified the roles of two different proteins in metastasis, suggesting potential new therapeutic strategies to treat cancer. One study proposes agonizing the membrane protein CD151 to prevent cancer cells from mobilizing at...
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