BioCentury | Jan 1, 2021
Targets & Mechanisms

A snapshot of target innovation in 2020

...Schistosoma mansoni TAO kinase 1 TERT - Telomerase...
...1 alpha-2-macroglobulin receptor (LRP1) (CD91) Double homeobox 4 (DUX4) Telomerase...
BioCentury | Apr 1, 2020
Distillery Therapeutics

Base editor correction of TERT promoter mutations for glioma

...non-PDX mouse models of glioma, the gene therapy reduced tumor growth and prolonged survival. TARGET/MARKER/PATHWAY: Telomerase...
...University School of Medicine, Hangzhou, China email: zhiminlu@zju.edu.cn Claire Quang Chinese Academy of Sciences Zhejiang University School of Medicine Telomerase...
BioCentury | Mar 19, 2020
Product Development

March 18 Quick Takes: Duo of Phase III data for Pfizer; plus Sage, Allergan-AbbVie, Merck, DermTech, Beijing Tide-Insilico

...JAK-1 - Janus kinase-1 P2X3 - Purinergic receptor P2X ligand-gated ion channel 3 TERT - Telomerase...
...Inc. AbbVie Inc. Merck & Co. Inc. Sage Therapeutics Inc. Pfizer Inc. Interleukin-23 (IL-23) Purinergic receptor P2X ligand-gated ion channel 3 (P2X3) Telomerase...
BioCentury | Jul 25, 2019
Distillery Therapeutics

A benzoylphenylurea-based stabilizer of TERT G-quadruplex DNA for prostate cancer

...developing additional small molecules that interact with G-quadruplex DNA for prostate cancer and glioblastoma. TARGET/MARKER/PATHWAY: Telomerase...
...hurley@reglagene.com CONTACT: Andrew S. Kraft, University of Arizona, Tucson, Ariz. email: akraft@uacc.arizona.edu Hongjiang Li Reglagene LLC University of Arizona Telomerase...
BioCentury | Jun 11, 2019
Distillery Therapeutics

Inhibiting FANCM-TOP3A-RMI1 interaction for osteosarcoma, Lesch-Nyhan syndrome

...help treat osteosarcoma and Lesch-Nyhan syndrome. In two human osteosarcoma cell lines and a human telomerase...
BioCentury | Jan 17, 2019
Emerging Company Profile

Zelluna’s solid TCR plans

...Targets HLA - Human leukocyte antigen KRAS (K-Ras) TCR - T cell receptor TERT - telomerase...
...factor β receptor II Jennie Walters, Staff Writer Zelluna Immunotherapy A/S Human leukocyte antigen (HLA) K-Ras (KRAS) T cell receptor (TCR) Telomerase...
BioCentury | Sep 28, 2018
Company News

Geron shares fall after Janssen returns imetelstat rights

...the hold was lifted later that year, Janssen and Geron struck a deal for the telomerase...
...supply imetelstat for up to 24 months during manufacturing transition. Allison Johnson imetelstat (GRN163L, JNJ-63935937) Geron Corp. Johnson & Johnson Telomerase Myelodysplastic...
BioCentury | Sep 28, 2018
Company News

Geron shares fall after Janssen discontinues partnership

...the hold was lifted later that year, Janssen and Geron struck a deal for the telomerase...
...Calif. Johnson & Johnson (NYSE:JNJ), New Brunswick, N.J. Business: Hematology Allison Johnson imetelstat (GRN163L, JNJ-63935937) Geron Corp. Johnson & Johnson Telomerase Myelodysplastic...
BioCentury | Sep 14, 2018
Company News

Telo, GSK targeting TERT to halt glioblastoma cell immortality

...on Sept. 10. At least nine companies have therapeutics or vaccines in the clinic targeting telomerase...
...cancers, and GemVax & Kael Co. Ltd. (KOSDAQ:082270) markets Riavax, a cancer vaccine targeting human telomerase...
...plc Telo Therapeutics Inc. University of California San Francisco GA binding protein transcription factor subunit beta 1 (GABPB1) (NRF2B1) Telomerase...
BioCentury | Jul 18, 2018
Emerging Company Profile

Ministring theory in practice

...Waterloo who invented the technology. Ministring manufacturing uses a bacterial strain with an inducible bacteriophage telomerase...
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