BioCentury | Jun 1, 2019
Product Development

ASCO 2019 abstracts show solid tumor race heating up among bispecifics and CAR Ts

...cellular cytotoxicity (ADCC) over conventional chimeric antibody chEBU-141 IgG1 University of Kiel e14004 Fusion proteins FGFR1-TACC1...
...exome sequencing identified activation of FGFR pathway with fibroblast growth factor (FGF) receptor 1 (FGFR1; CD331)/transforming acidic coiled-coil containing protein 1 (TACC1)...
BioCentury | Jun 29, 2017
Translation in Brief

New Therapeutic Targets and Biomarkers: June 2017

...and mouse studies suggest jointly inhibiting phosphoinositide 3-kinase (PI3K) and either ZFR, ZNF565, Pim-2 (PIM2), transforming acidic coiled-coil containing protein 1 (TACC1)...
BioCentury | Jun 7, 2017
Distillery Therapeutics

Cancer

...Breast cancer Cell culture and mouse studies suggest jointly inhibiting PI3K and either PIM2 , TACC1...
...cancer cell line treated with a pan-PI3K inhibitor tool compound identified five genes -- PIM2, TACC1...
...mouse model of breast cancer, intratumoral delivery of the PI3K inhibitor plus siRNAs targeting PIM2, TACC1...
BioCentury | Jun 10, 2013
Company News

Qiagen, British Columbia Cancer Agency, Columbia University deal

Qiagen entered two exclusive license agreements for cancer biomarkers that the company plans to use to develop diagnostics. The company licensed worldwide rights from the university to fibroblast growth factor (FGF) receptor ( FGFR )-transforming acidic...
BioCentury | Aug 30, 2012
Distillery Therapeutics

Indication: Cancer

...Licensing status Publication and contact information Cancer Brain cancer Fibroblast growth factor receptor (FGFR); FGFR3; transforming acidic coiled-coil containing protein 1 (TACC1)...
...driven by FGFR-TACC fusion proteins. In mice, subcutaneous injection of human primary astrocytes expressing the FGFR3-TACC1...
BioCentury | Aug 16, 2012
Distillery Techniques

Technology: Assays & screens

...toxin substrate 1 (rho family, small GTP binding protein Rac1; RAC1), sorting nexin 31 (SNX31), transforming acidic coiled-coil containing protein 1 (TACC1)...
BioCentury | Apr 22, 2010
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Bladder cancer Fibroblast growth factor receptor 3 (FGFR3; CD333); transforming, acidic coiled-coil containing protein 3 (TACC3) A genomewide association study identified a SNP in TACC3...
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