BioCentury | Nov 21, 2019

PGAM1 inhibition to treat pancreatic cancer

...online Oct. 29, 2019 doi:10.1073/pnas.1914557116 CONTACT: Zhu Chen, Shanghai Jiao Tong University, Shanghai, China email: zchen@stn.sh.cn...
BioCentury | Aug 21, 2019
Company News

Interest in carbohydrate antigens grows with Siamab acquisition

...The company's lead candidate, ST1 ADC, is a humanized mAb against the tumor-associated carbohydrate sTn...
BioCentury | Apr 10, 2018
Distillery Techniques

Drug platforms

...School of Medicine, Shanghai, China email: liuhan68@sjtu.edu.cn CONTACT: Sai-Juan Chen, same affiliation as above email: sjchen@stn.sh.cn...
BioCentury | Nov 2, 2017
Product R&D

Sweet specificity

...epitope Phase I Siamab Therapeutics Inc. 2006 $11.8 ST1 ADC ADC composed of a sialosyl-Tn antigen (sTn...
...the tumor-associated carbohydrate sTn , linked to the cytotoxic warhead monomethyl auristatin E (MMAE). Because sTn...
...tumors.” The company also showed anti-sTn mAbs from its platform could be used to detect sTn...
BioCentury | Oct 10, 2016
Clinical News

Siamab Therapeutics preclinical data

...In a mouse xenograft model of ovarian cancer, Siamab’s ST1 ADC composed of a sialosyl-Tn antigen (sTn...
BioCentury | Apr 14, 2015
Politics & Policy

Regulators support C-Path's skeletal muscle biomarkers

FDA and EMA issued Letters of Support for four skeletal muscle biomarkers identified by the Predictive Safety Testing Consortium (PSTC) of the Critical Path Institute (C-Path). Elevated levels of myosin light chain 3 ( MYL3 ),...
BioCentury | Oct 17, 2013
Distillery Therapeutics

Indication: Neurology

...Dopamine D5 receptor Studies in rodents suggest inhibiting dopamine D5 receptor in the subthalamic nucleus (STN...
...brain slices from normal and dopamine-depleted rats, the inverse agonist decreased burst firing in the STN...
BioCentury | Feb 17, 2011
Distillery Therapeutics

Indication: Cancer

...School of Medicine, Shanghai, China e-mail: sjchen@stn.sh.cn Contact: Zhu Chen, same affiliation as above e-mail: zchen@stn.sh.cn...
BioCentury | Jul 9, 2009
Distillery Techniques

Technology: Drug delivery

...published online June 15, 2009; doi:10.1021/ja9017336 Contact: SonBinh T. Nguyen, Northwestern University, Evanston, Ill. e-mail: stn@northwestern.edu...
BioCentury | Jul 9, 2009
Distillery Therapeutics

Indication: Cancer

...cancer; prostate cancer Globohexaosylceramide (globo-H); ganglioside GM2 (GM2); Thomsen-Friedenreich antigen (TF); Tn antigen (Tn); sialosyl-Tn antigen (sTn...
...was produced by conjugating five breast and prostate cancer-associated carbohydrate antigens-globo-H, GM2, TF, Tn and sTn-to...
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