BioCentury | Aug 28, 2019
Translation in Brief

Guiding antibody-drug conjugates from circulation to cytoplasm

A linchpin for the efficacy of antibody-drug conjugates is ensuring the payload travels from the circulation, to the endosomal pathway, and ultimately into the cytoplasm. A new study by Stanford University researchers uncovers biological pathways...
BioCentury | Oct 15, 2015
Distillery Therapeutics

Therapeutics: Glycinamide ribonucleotide formyltransferase (GARFT); folate receptor 1 (FOLR1; FR-α); FOLR2 (FR-β); solute carrier family 46 folate transporter m

...Cancer Mouse and cell studies identified an inhibitor of GARFT , FOLR1 , FOLR2 and SLC46A1...
...GARFT with Ki of 9.1 nM. In CHO cells, the compound inhibited FOLR1, FOLR2 and SLC46A1...
...TARGET/MARKER/PATHWAY: Glycinamide ribonucleotide formyltransferase (GARFT) ; folate receptor 1 (FOLR1; FR-α); FOLR2 (FR-β); solute carrier family 46 folate transporter member 1 (SLC46A1; PCFT...
BioCentury | Mar 17, 2011
Distillery Techniques

Technology: Disease models

...of folate deficiency Mice lacking the folate transporter solute carrier family 46 member 1 (Slc46a1; Pcft...
...Pcft) could be useful for evaluating treatments for folate deficiency. Mice with low levels of Pcft...
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