BioCentury | Jan 21, 2021
Product Development

Jan. 20 Quick Takes: AZ, Daiichi get Enhertu approvals in gastric, breast cancer; plus EdiGene, Merck, Oxford, BMS and Omeros

...approval, which includes a black box warning describing risks of fetal harm, marks the first for an sGC...
...neu) – Epidermal growth factor receptor 2PD-1 (PDCD1; CD279) – Programmed cell death 1sGCSoluble guanylate cyclase Stephen...
BioCentury | Oct 16, 2020
Product Development

Recent Phase III disappointment aside, the heart failure pipeline holds plenty to look forward to

...two other mechanisms —cadiac myosin activation and sGC...
...a tough sell to either regulators or payers.sGC...
...advanced of three molecules that activate the NO-sGC-cGMP...
BioCentury | Jan 28, 2020
Clinical News

Acceleron readout supports sotatercept as disease-modifying option for PAH

...of pulmonary artery walls. The existing drugs -- prostacyclins, endothelin receptor antagonists, PDE-5 inhibitors and sGC...
...receptor type II; NT-proBNP - N-terminal pro-brain natriuretic peptide; PDE-5 (PDE-5A) - Phosphodiesterase-5; sGC - Soluble guanylate cyclase Sandi...
BioCentury | Nov 18, 2019
Clinical News

Heart failure notches another win as Merck, Bayer's sGC stimulator meets in Phase III

...chronic heart failure with reduced ejection fraction (HFrEF). Merck & Co. Inc. (NYSE:MRK) said the sGC...
...AG (NYSE:NVS; SIX:NOVN) at baseline. Merck and Bayer AG (Xetra:BAY) are co-developing vericiguat and other sGC-targeted...
...intravenous diuretic for heart failure without hospitalization. The VICTORIA data comes just weeks after another sGC...
BioCentury | Oct 30, 2019
Clinical News

Ironwood spinout sees path forward for platform despite lead program miss

...Therapeutics Inc. (NASDAQ:CYCN) shares fell $10.68 (80%) to $2.75 after the company announced its lead soluble guanylate cyclase (sGC)...
...spun out of Ironwood Pharmaceuticals Inc. (NASDAQ:IRWD) in April with a pipeline of candidates targeting sGC...
...months, Cyclerion expects additional data from its other sGC pipeline programs, including olinciguat, a vascular sGC...
BioCentury | May 20, 2019
Distillery Therapeutics

Cyclerion's sGC stimulator praliciguat ameliorates NASH in rodents

...sGC stimulator praliciguat could help treat NASH. In liver samples from patients, levels of an sGC...
...than in non-fibrotic tissue. In a rat model of NASH, praliciguat increased levels of cGMP, sGC's...
...a marker of liver fibrosis. Next steps by Cyclerion Therapeutics Inc. include developing a liver-specific sGC...
BioCentury | May 14, 2019
Preclinical News

Cyclerion's sGC activation could work for NASH

...new preclinical data in hand, Ironwood-spinout Cyclerion is making the case for extending its lead sGC...
...Inc. (NASDAQ:IRWD) in April with a pipeline of five soluble guanylate cyclase (sGC) programs, including praliciguat, a systemic sGC...
...mouse model of diet-induced NASH and in rats with NASH. Wright said the data validate sGC...
BioCentury | Apr 12, 2019
Financial News

Cyclerion launches, raises $175M private placement

...Cyclerion Planning $175M Private Placement" ). Cyclerion Therapeutics Inc. (NASDAQ:CYCN) has a pipeline of five soluble guanylate cyclase (sGC)...
...its gastrointestinal business (see "Splitting Ironwood" ). Mary Romeo, Staff Writer IW-6463 olinciguat (IW-1701) Praliciguat, IW-1973 Cyclerion Therapeutics Inc. Ironwood Pharmaceuticals Inc. Soluble guanylate cyclase (sGC)...
BioCentury | Apr 9, 2019
Company News

Management tracks: Cyclerion, Alkermes, Alder

...Therapeutics Inc. (NASDAQ:CYCN) raised $175 million in a private placement. The company’s pipeline comprises five soluble guanylate cyclase (sGC)...
BioCentury | Feb 28, 2019
Financial News

Ironwood spinout Cyclerion planning $175M private placement

...become president of Cyclerion; both will become members of Cyclerion's board. Cyclerion will have five soluble guanylate cyclase (sGC)...
...26. Ironwood Pharmaceuticals Inc. (NASDAQ:IRWD), Cambridge, Mass. Cyclerion Therapeutics Inc., Cambridge, Mass. Hongjiang Li IW-1701 IW-6463 Praliciguat, IW-1973 Ironwood Pharmaceuticals Inc. Soluble guanylate cyclase (sGC)...
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