BioCentury | May 20, 2019
Distillery Therapeutics

USP1 and SNAI1 identified as targets in ovarian cancer

DISEASE CATEGORY: Cancer INDICATION: Ovarian cancer Patient sample, cell culture and mouse studies suggest inhibiting USP1 or its deubiquitination target SNAI1 could help treat ovarian cancer. In patients, high tumor levels of USP1 mRNA were...
BioCentury | Apr 30, 2019
Finance

Why liver disease newco Alentis is aiming for one of largest Swiss A rounds

...the yet unnamed lead program, Alentis isn’t waiting for the data to raise the next slug...
BioCentury | May 26, 2017
Finance

Europe’s bellwether challenge

...company is that interested in us, why don’t we go out and raise a big slug...
BioCentury | Jan 18, 2017
Distillery Therapeutics

Cancer

...lung cancer. In patients with non-small cell lung cancer (NSCLC) tumors that overexpressed the metastasis-promoting SNAI2...
...could include identifying a therapeutic that upregulates DAXX. TARGET/MARKER/PATHWAY: Death-domain associated protein (DAXX); snail family transcriptional repressor 2 (SNAI2; SLUG...
...Yang, Academia Sinica, Taipei, Taiwan email: pcyang@ntu.edu.tw Lauren Martz Academia Sinica National Cheng Kung University Death-domain associated protein (DAXX) Snail family transcriptional repressor 2 (SNAI2...
BioCentury | May 16, 2016
Emerging Company Profile

EMT interrupted

Oncodrone B.V. is developing a small molecule that can disrupt the epithelial-mesenchymal transition to prevent tumor cells from gaining invasive and malignant properties. The biotech plans to develop the compound for aggressive tumors such as...
BioCentury | Mar 3, 2016
Translation in Brief

Notching up differences

...genes that directly control MET such as twist homolog 1 (TWIST1) and snail 2 ( SNAI2...
BioCentury | May 28, 2015
Distillery Therapeutics

Therapeutics: v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS); snail 2 (SNAI2)

...Neurology INDICATION: Neurology Cell culture and mouse studies suggest reducing HRAS overactivation or inhibiting SNAI2 could...
...patient-derived iPS cells, a farnesyl transferase inhibitor that reduces HRAS overactivity or an siRNA targeting SNAI2...
...in neurodevelopmental disorders. TARGET/MARKER/PATHWAY: v-Ha-ras Harvey rat sarcoma viral oncogene homolog (HRAS) ; snail 2 (SNAI2...
BioCentury | Oct 9, 2014
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Cancer F-box protein 11 (FBXO11); snail1 (SNAI1) Mouse and cell culture studies suggest promoting FBXO11-mediated degradation of SNAI1 could help prevent cancer and metastasis. SNAI1...
BioCentury | Apr 3, 2014
Targets & Mechanisms

Narrowing down graft stenosis

...Smad2 ) and Smad3 ( Madh3 ) activated the snail family zinc finger 2 (Snai2; Slug...
BioCentury | Aug 1, 2013
Targets & Mechanisms

Activating memory

Despite more than a decade of research suggesting histone acetyltransferases play a role in learning and memory, the targets have proven difficult to selectively activate in the brain. Now, a French and Indian team has...
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