BioCentury | Nov 3, 2017

Frame work

A little over four years into its implementation, FDA’s structured benefit-risk framework appears to be meeting its objectives of creating transparency into its approval decisions. The agency began to incorporate the framework templates into its...
BioCentury | May 19, 2016
Distillery Therapeutics

Therapeutics: Solute carrier organic anion transporter family member 2A1 (SLCO2A1)

Endocrine/metabolic disease INDICATION: Contraception Human sample and mouse studies suggest inhibiting SLCO2A1 could help create a female contraceptive. In primary tissue samples from healthy volunteers, levels of SLCO2A1 were higher in granulocytes from post-ovulatory follicles...
BioCentury | Mar 31, 2016
Distillery Techniques

Drug properties

...involving SLCO1B1 and SLCO1B3 . In a human cell line, overexpression of human SLCO1B1 or SLCO1B3...
...In the SLCO1B1/1B3-overexpressing cell line and in human hepatocytes, rifampicin - an inhibitor of SLCO1B1, SLCO1B3...
...of solute carrier organic anion transporter family member 1B1 (SLCO1B1; OATP2 ) and SLCO1B3 ( OATP8...
BioCentury | Jun 4, 2012
Company News

Boston Heart Diagnostics sales and marketing update

Boston Heart Diagnostics launched its Statin Induced Myopathy (SLCO1B1) Genotype test in the U.S. to identify patients at higher risk for developing severe myopathy as a side effect of statins. The test will be performed...
BioCentury | May 24, 2010
Company News

Optivia Biotechnology Inc. sales and marketing update

...anion transporter family member 1B1 ( SLCO1B1 ; OATP2 ); and solute carrier organic anion transporter family member 1B3 ( SLCO1B3 ; OATP8...
BioCentury | Aug 25, 2008
Clinical News

Zocor simvastatin metabolic data

In a genome-wide association study, the rs4363657 SNP located within the SLCO1B1 gene showed a strong association of myopathy in patients with myocardial infarction (MI) receiving 80 mg Zocor simvastatin daily (p<0.0001). The study examined...
BioCentury | Aug 14, 2008
Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/marker/ pathway Summary Licensing status Publication and contact information Cardiovascular disease Statin-induced myopathy Solute carrier organic anion transporter family, member 1B1 (SLCO1B1) A genome-wide association study identified a SNP located...
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