BioCentury | Jun 11, 2020

Cullinan adds first-in-class asset in hot NK cell checkpoint space

The latest addition to Cullinan’s oncology portfolio is a mAb against MICA that’s set to become the first compound in the clinic against the NK cell target. Through a deal announced on Thursday, Cullinan Oncology...
BioCentury | Feb 5, 2019
Distillery Techniques

Assays and screens

TECHNOLOGY: Activation assays A method for engineering protease-inducible Cas9 proteins could be used to screen for protease-activating drug compounds. Generation of a protease-inducible Cas9 (ProCas9) involves two steps: inactivating Cas9 by circular permutation, a process...
BioCentury | Feb 9, 2012
Distillery Therapeutics

Indication: Infectious disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease HCV Membrane-bound transcription factor peptidase site-1 (MBTPS1; SKI-1) Cell culture studies suggest inhibiting SKI-1 could help treat HCV infection. In cultured hepatocytes, a small...
BioCentury | Jun 19, 2008
Distillery Therapeutics

This Week in Therapeutics

This week in therapeutics Indication Target/ marker/pathway Summary Licensing status Publication and contact information Cancer Acute myelogenous leukemia (AML), leukemia Sphingosine kinase 1 (SphK1) Studies in cancer cells and in mice suggest that inhibitors specific...
BioCentury | Jun 19, 2008
Targets & Mechanisms

SK1-I is the Limit in AML

A paper published in Blood suggests that going upstream of the known cancer target sphingosine 1-phosphate could be a better approach than hitting site-1 protease ( S1P ) itself. By specifically hitting one of the two sphingosine...
BioCentury | Jun 12, 2008
Targets & Mechanisms

Eyeing New Uses for Protease Inhibitors

A paper in the Journal of Clinical Investigation indicates that HIV protease inhibitors could be repurposed as neuroprotectants to block apoptosis in age-related macular degeneration, diabetic retinopathy and other conditions involving neuronal apoptosis. 1 The...
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