Juvenescence Ltd. (Douglas, Isle of Man), Insilico Medicine Inc. (Baltimore, Md.) and the Buck Institute for Research on Aging (Novato, Calif.) partnered to form anti-aging company Napa Therapeutics Ltd. (Tortola, British Virgin Islands). Napa will...

Juvenescence Ltd. (Douglas, Isle of Man), Insilico Medicine Inc. (Baltimore, Md.) and the Buck Institute for Research on Aging (Novato, Calif.) partnered to form anti-aging company Napa Therapeutics Ltd. (Tortola, British Virgin Islands). Napa will...

INDICATION: Neurology Cell culture and mouse studies suggest promoting the expression of SIRT1 could help treat Alzheimer’s disease and other neurodegenerative tauopathies. In HEK cells expressing mutant human tau, plasma vector-encoded SIRT1 decreased levels of...

While it’s no surprise that cell therapy research is dominant in hematology, the emergence of epigenetics as an equally large focus at this year’s ASH meeting is more notable, reinforcing the resurgence of a field...

A study published in Cell Metabolism by researchers at Medical University of South Carolina and colleagues showed that the enhanced antitumor effect of a hybrid of T helper types 1 (Th1) and 17 (Th17) cells...

INDICATION: Osteoarthritis Patient sample and mouse studies suggest inhibiting SIRT1 could help treat osteoarthritis. In cartilage samples from patients, levels of activated DOT1L , a negative regulator of SIRT1, were lower than in samples from non-arthritic...

  A trio of studies has converged on a common pathway, headed by the PPAR co-activator PGC-1α , to fight cancer and chronic infections by manipulating either T cell immunotherapies or the tumors themselves. While the...

Since sirtuins hit the scene as modulators of numerous cellular pathways over 20 years ago, the enzymes have been implicated in metabolic diseases, aging and cancer. Now Forge Life Science LLC has licensed findings from...

Neurology INDICATION: Ataxia Patient sample and mouse studies suggest promoting SIRT1 activity could help treat spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disease caused by mutant ATXN3 encoding polyglutamine repeats. Levels of SIRT1 were lower...

Biomarkers TECHNOLOGY: SNPs Genetic sequencing studies identified two new susceptibility loci on chromosome 10 that could help predict risk of MDD. In 5,303 Han Chinese women with recurrent MDD and 5,337 non-depressed controls and validation...