BioCentury | Apr 16, 2021
Targets & Mechanisms

New targets featured at AACR signal growing opportunity in established mechanisms

The bulk of the new targets presented at AACR21 involve pathways and mechanisms active in tumor cells rather than immune cells, reflecting the biotech industry’s growing interest in targeted oncology and...
BioCentury | Dec 31, 2020
Distillery Therapeutics

SIRT5 overexpression could rescue mitochondrial disease induced by SUCLA2 mutations

DISEASE CATEGORY: Endocrine/metabolic INDICATION: Mitochondrial disease Promoting the expression of the desuccinylase SIRT5 could treat a hereditary mitochondrial encephalomyopathy caused by succinyl-CoA ligase deficiency, which is some patients results from mutations in the tricarboxylic acid...
BioCentury | Nov 6, 2018
Distillery Therapeutics

Cancer

INDICATION: Liver cancer In silico , in vitro , cell culture and mouse studies identified a positive allosteric modulator (PAM) of SIRT6 that could help treat hepatocellular carcinoma (HCC). In silico screening of a small molecule library...
BioCentury | Aug 17, 2018
Company News

Juvenescence, partners form anti-aging biotech

...metabolism. Verdin has authored several papers on the roles of NAD+-dependent sirtuins, such as sirtuin 1 (SIRT1...
BioCentury | Aug 14, 2018
Company News

Juvenescence, partners form anti-aging biotech

...metabolism. Verdin has authored several papers on the roles of NAD+-dependent sirtuins, such as sirtuin 1 (SIRT1...
BioCentury | Apr 17, 2018
Distillery Therapeutics

Neurology

...INDICATION: Neurology Cell culture and mouse studies suggest promoting the expression of SIRT1 could help treat...
...and testing promoters of SIRT1 expression in models of AD and other tauopathies. TARGET/MARKER/PATHWAY: Sirtuin 1 (SIRT1...
...of Neurological Disease, San Francisco, Calif. email: lgan@gladstone.ucsf.edu Jennie Walters Gladstone Institutes Microtubule-associated protein tau (tau) (MAPT) (FTDP-17) Sirtuin 1 (SIRT1...
BioCentury | Jan 31, 2018
Distillery Therapeutics

Cancer

INDICATION: Bone cancer; colorectal cancer Cell culture and mouse studies suggest inhibiting SIRT5-mediated desuccinylation of SHMT2 could help treat osteosarcoma and colorectal cancer. In a human osteosarcoma cell line, knockout of SIRT5 increased levels of...
BioCentury | Dec 8, 2017
Targets & Mechanisms

Epiphenomena at ASH

...Three groups show Tet2 activity in cancer cells is upregulated in response to a tool SIRT1...
...homology protein tyrosine phosphatase 2 SIGLEC7 - Sialic acid binding Ig-like lectin 7 SIRT1 - Sirtuin 1...
...member 1 (NKG2D) (KLRK1) (CD314) Lysine-specific demethylase 1 (LSD1) (KDM1A) Poly(ADP-ribose) polymerase (PARP) Protein arginine methyltransferase 5 (PRMT5) Sirtuin 1 (SIRT1) SLAM...
BioCentury | Nov 14, 2017
Preclinical News

Hybrid T cells show anticancer effects

...T helper types 1 (Th1) and 17 (Th17) cells was dependent on activity of sirtuin 1 (SIRT1...
...the hybrid cells was dependent on the increased nicotinamide adenine dinucleotide (NAD+)-dependent activity of SIRT1. SIRT1...
...and antitumor function. Jaime De Leon Medical University of South Carolina CD38 Interferon (IFN) gamma Interleukin-17 (IL-17) Nicotinamide adenine dinucleotide (NAD+) Sirtuin 1 (SIRT1...
BioCentury | Oct 3, 2017
Distillery Therapeutics

Cancer

INDICATION: Breast cancer Patient sample, cell culture and mouse studies suggest activating SIRT7 or promoting its expression could help treat metastatic breast cancer. In samples from metastatic breast cancer patients, levels of SIRT7 were lower...
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