BioCentury | Oct 27, 2020
Distillery Therapeutics

ZDHHC7 and LYPLA2 identified as targets in Crohn’s, ulcerative colitis

...membrane localization of the Th17-cell differentiation stimulator STAT3...
...finger DHHC-type containing 7 (ZDHHC7); lysophospholipase 2 (LYPLA2); Signal transducer and activator of transcription 3 (STAT3)EXPERIMENTAL...
BioCentury | Oct 23, 2020
Product Development

What’s next for targeted protein degradation

...of the PK/PD relationship for the company’s STAT3...
...GTPase MYC (c-Myc) – v-myc myelocytomatosis viral oncogene homolog STAT3...
BioCentury | Oct 8, 2020
Product Development

COVAX nears $2B fund-raising goal for equitable vaccine distribution; plus Novartis-Merck KGaA, 10x Genomics, Alkermes, UCB-Aetion, Janpix, BeiGene-BioAtla, Phenomic AI

...lead molecule into the clinic in patients with hematological cancers and expand its pipeline of STAT3...
...Mu opioid receptorSTAT3Signal transducer and activator of transcription 3 STAT5 – Signal transducer and activator of transcription 5 BC Staff Janpix Inc. Signal transducer and activator of transcription 3 (STAT3) Signal...
BioCentury | Sep 17, 2020
Deals

Awaiting dialogue with FDA on GI program, microbiome play Finch looks to autism, HBV with new $90M round

With one pivotal readout in Clostridium difficile already achieved, microbiome company Finch has tapped investors for a $90 million series D round that will fund additional programs, and potentially help...
BioCentury | Jun 27, 2020
Translation in Brief

Regeneron enhances checkpoint therapy with CD28 bispecifics; plus NIH funds Alzheimer’s brain mapping, Genentech and more

...expressed JAK-STAT pathway genes and that cancer-associated fibroblasts highly expressed JAK-STAT ligands. A JAK2 and STAT3...
...Janus kinase-2 PARP - poly(ADP-ribose) polymerase PSMA (FOLH1) (GCPII) - Prostate-specific membrane antigen STAT3 - signal transducer and activator of transcription 3...
...GCPII) Programmed cell death 1 (PD-1) (PDCD1) (CD279) Epidermal growth factor receptor (EGFR) (ErbB1) (HER1) Janus kinase-2 (JAK-2) Signal transducer and activator of transcription 3 (STAT3...
BioCentury | Jun 27, 2020
Product Development

A mechanistic view of four compounds that disrupt interleukin pathways to treat severe COVID-19

Master protocols for COVID-19 clinical trials are testing half a dozen molecules that aim to prevent respiratory distress in patients with severe disease by targeting the host immune system -- four of these compounds intervene...
BioCentury | Jun 22, 2020
Emerging Company Profile

Prosit Sole: chimeric proteins for rare disease

Prosit Sole is improving upon protein and cytokine therapies against validated targets for rare diseases using its chimeric protein engineering platform. The idea is to combine desirable structural features from different protein family members to...
BioCentury | Jun 11, 2020
Product Development

Emerging COVID-19 serology tests aim for neutralizing antibodies

The next wave of serology tests from big diagnostic players could get closer to telling people whether they are protected from COVID-19 by homing in on the antibodies most likely to block viral entry into...
BioCentury | May 1, 2020
Distillery Therapeutics

Thioredoxin reducing enzyme inhibitors for solid tumors

...inactive, oxidized STAT3. Cell-based screening of 28,000 small molecules identified three dichloropyridazinone-based compounds that reduced STAT3-dependent...
...IC 50 values under 7.5 μM. TARGET/MARKER/PATHWAY: Thioredoxin reductase 1 (TXNRD1; TRXR1; TR1; GRIM-12); signal transducer and activator of transcription 3 (STAT3...
...Page, Karolinska Institute, Stockholm, Sweden; University of British Columbia, Vancouver, B.C. email: brent.page@ki.se Claire Quang Karolinska Institute Thioredoxin Signal transducer and activator of transcription 3 (STAT3...
BioCentury | Apr 23, 2020
Product Development

First glimpse of controlled remdesivir data cast doubt on its COVID-19 treatment potential

After weeks of encouraging anecdotal and uncontrolled data for Gilead’s COVID-19 therapy remdesivir, the first hint of results from a placebo-controlled trial suggest that if the antiviral does provide a benefit, it may be closely...
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