BioCentury | Jan 31, 2018
Distillery Therapeutics

Cancer

...INDICATION: Bone cancer; colorectal cancer Cell culture and mouse studies suggest inhibiting SIRT5-mediated desuccinylation of SHMT2...
...include identifying and testing inhibitors of SHMT2 desuccinylation in osteosarcoma and colorectal cancer models. TARGET/MARKER/PATHWAY: Serine hydroxymethyltransferase 2 mitochondrial (SHMT2)...
...online Nov. 27, 2017 doi:10.1158/0008-5472.CAN-17-1912 CONTACT: Jianyuan Luo, Peking University, Beijing, China email: luojianyuan@bjmu.edu.cn Winnie Pong Peking University Serine hydroxymethyltransferase 2 mitochondrial (SHMT2) Sirtuin...
BioCentury | Oct 17, 2017
Distillery Therapeutics

Cancer

...B cell lymphoma; colorectal cancer In vitro , cell culture and mouse studies suggest inhibiting SHMT2...
...and testing in vitro of a previously identified pyrazolopyran-based compound yielded two compounds that inhibited SHMT2...
...compared with normal SHMT2 expression. Ongoing work includes optimizing the compounds' in vivo activity. TARGET/MARKER/PATHWAY: Serine hydroxymethyltransferase 2 mitochondrial (SHMT2)...
BioCentury | Jun 5, 2014
Distillery Therapeutics

Indication: Cancer

...Proteasome subunit-b type 4 (PSMB4); serine hydroxymethyltransferase 2 mitochondrial (SHMT2) In vitro and mouse studies suggest inhibiting PSMB4 or SHMT2...
...human cancers and conducting functional RNAi screening identified new potential oncogenic drivers including PSMB4 and SHMT2...
...survival compared with wild-type PSMB4 expression. In multiple human tumor types, expression of PSMB4 and SHMT2...
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