BioCentury | Feb 3, 2021
Deals

Imcyse moves closer to next financing round with Pfizer RA deal

...presenting cells (APCs) that present the target autoantigen, leading to the selective depletion of autoantigen-presenting APCs...
BioCentury | Jan 16, 2021
Politics, Policy & Law

Woodcock’s appointment as acting FDA commissioner could be audition for permanent position

Politics, Policy & Law When Janet Woodcock moves into the FDA commissioner’s office next week, she will take charge, at least on an acting basis, of an agency that has been pummeled for months. President...
BioCentury | Jan 1, 2021
Targets & Mechanisms

A snapshot of target innovation in 2020

Preclinical publications highlighted in BioCentury’s Distillery this year identified white space target opportunities including untapped E3 ubiquitin ligases, vesicular regulators and ion channels, as...
BioCentury | Oct 31, 2020
Regulation

Expanding access to COVID-19 vaccines

...the potential for unexpected adverse effects to sap...
BioCentury | Jun 26, 2020
Distillery Therapeutics

Promoting Golgi fragmentation to treat pancreatic cancer

DISEASE CATEGORY: Cancer INDICATION: Pancreatic cancer Inducing Golgi complex fragmentation by inhibiting the transcription factor KLF7 or the Golgi integrity maintenance factors DLG3 or STX5 could treat pancreatic ductal adenocarcinoma (PDAC). In pancreas samples from...
BioCentury | May 18, 2020
Finance

$65M round positions SQZ Biotech for potential IPO, 2021 catalysts

...in combination with Tecentriq atezolizumab to treat HPV16-positive tumors. SQZ-PBMC-HPV consists of engineered antigen-presenting cells (APCs...
...Activating Antigen Carriers (AAC) technology, which uses red blood cells to deliver target antigens to APCs...
...has initially been focused on cancer, SQZ said the financing will allow it to expand APCs...
BioCentury | May 16, 2020
Product Development

A guide to COVID-19 preclinical vaccine modalities

...source of antigens, or as a platform to deliver antigens. A common method involves delivering APCs...
...two companies have developed cellular vaccine platforms that promote antigen uptake and presentation by endogenous APCs...
...cells expressing membrane-bound SARS-CoV-2 spike proteins. These cells are targeted by NK cells and recruit APCs...
BioCentury | Jan 18, 2020
Product Development

Charting a course to intercepting Type I diabetes

...The goal is to stop the pathological immune response through selective depletion of the autoantigen-presenting APCs...
BioCentury | Jan 11, 2020
Targets & Mechanisms

Colitis-associated somatic mutations yield new colorectal cancer target

Kyoto University team identifies colitis-associated somatic mutations that are lost in colitis-associated cancer to reveal a new colorectal cancer target. A Japanese team has identified novel colorectal cancer targets by contrasting somatic mutations in cancerous...
BioCentury | Feb 28, 2019
Distillery Therapeutics

Cancer

INDICATION: Colorectal cancer Mouse studies suggest inhibiting the Wnt enhanceosome components BCL9, PYGO1 and/or PYGO2 could help treat APC-mutant colorectal cancer. In a mouse model of APC-mutant colorectal cancer, intestinal epithelium-specific knockout of BCL9, PYGO1...
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