DISEASE CATEGORY: Cancer INDICATION: Melanoma; breast cancer Inhibiting SERPINB9, a serine protease inhibitor, could treat melanoma and breast cancer. In a melanoma mouse model, tumor-specific SERPINB9 knockout reduced tumor size and the number of melanoma...

New Therapeutic Targets and Biomarkers: August 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database in August 2018. Therapeutic targets are defined as any protein, gene or other...

While checkpoint inhibitors have revolutionized immunotherapy, many patients don't respond to the inhibitors, and there are currently no accurate diagnostics to predict who will respond. Two papers in Nature Medicine put forth algorithms that use...

New Therapeutic Targets and Biomarkers: October 2017 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during October 2017. Therapeutic targets are defined as any protein, gene or other...

Three genome-wide association studies (GWAS) have identified new genetic markers associated with an increased risk of food allergies and breast cancer. In a paper published in Nature Communications , researchers at the Max Delbrueck Center for...

While the predictive power and standardization of PD-L1 diagnostics is still being hashed out by clinical immuno-oncologists, companies and academics are casting a wide net for better biomarkers to forecast patient responses to checkpoint inhibitors....

TECHNOLOGY: Gene profiling Mutations in SERPINB3, SERPINB4 or IFNγ pathway genes could help predict responses to Yervoy ipilimumab in melanoma patients. In a cohort of 174 Yervoy -treated patients, tumor mutations in SERPINB3 or SERPINB4...