BioCentury | Apr 16, 2021
Targets & Mechanisms

New targets featured at AACR signal growing opportunity in established mechanisms

...1TIP1 (TAX1BP3) –Tax interacting protein 1TMPRSS13 –Transmembrane serine protease...
BioCentury | Jan 1, 2021
Targets & Mechanisms

A snapshot of target innovation in 2020

...cancer.  Repurposed targets include receptor tyrosine kinase ROR2, serine protease...
BioCentury | Dec 31, 2020
Distillery Therapeutics

Protease inhibitor SERPINB9 as a melanoma, breast cancer target

...By Claire Quang, Staff Writer DISEASE CATEGORY: CancerINDICATION: Melanoma; breast cancerInhibiting SERPINB9, a serine protease inhibitor, could...
BioCentury | Jul 29, 2020
Distillery Therapeutics

Inhibiting proteolytic activation of the receptor PAR2 for eosinophilic esophagitis

...DISEASE CATEGORY: Inflammation INDICATION: Eosinophilic esophagitis Inhibiting the extracellular serine protease KLK5 or its substrate PAR2 could...
BioCentury | Jun 1, 2019
Product Development

ASCO 2019 abstracts show solid tumor race heating up among bispecifics and CAR Ts

...is associated with worse survival outcomes Cleveland Clinic e14262 Zinc fingers and homeoboxes 2 (ZHX2); serine protease...
BioCentury | Jan 3, 2019
Translation in Brief

New Therapeutic Targets and Biomarkers: December 2018

...inhibiting KPNA1 could help treat anxiety Weizmann Institute of Science Distillery Therapeutics Biomarkers Gastrointestinal Pancreatitis Serine protease...
BioCentury | Dec 19, 2018
Distillery Therapeutics

Hematology

...treat bleeding. Chemical synthesis and in vitro testing of analogs of a sunflower cyclic peptide serine protease...
...of plasmin and a component of clots, the compound decreased fibrin degradation compared with the serine protease...
BioCentury | Dec 11, 2018
Distillery Techniques

Disease models

...steps include testing inhibitors of trypsin, a PRSS1 preprotein cleavage product, in the model. DESCRIPTION: Serine protease...
...Boston University Henry M. Goldman School of Dental Medicine, Boston, Mass. email: miklos@bu.edu Hongjiang Li Boston University Thymus serine protease...
BioCentury | Sep 26, 2018
Distillery Therapeutics

Cancer

...Heidelberg Pharma AG, Link Health Group and RedHill Biopharma Ltd. have Mesupron upamostat, a second-generation serine protease...
BioCentury | Aug 28, 2018
Preclinical News

Stealth start-up Quench among teams tying protein to inflammatory cell death

Atlas Venture-backed start-up Quench Bio has partnered with a Max Planck Institute for Infection Biology team to target an inflammatory cell death pathway implicated in inflammatory and autoimmune diseases. The company, which is funded by...
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