New Therapeutic Targets and Biomarkers: June 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during June 2018. Therapeutic targets are defined as any protein, gene or other...

TECHNOLOGY: Tissue markers Low esophageal levels of SPINK7 could help diagnose eosinophilic esophagitis. In esophageal tissue samples, SPINK7 protein and mRNA levels were lower in patients with eosinophilic esophagitis than in healthy volunteers, and the...

A major theme at this year’s AACR is the abundance of preclinical discovery driven by molecular signatures in patient samples, suggesting the research community is heeding the call for studies better grounded in human data,...

INDICATION: Nasopharyngeal cancer Patient sample, cell culture and mouse studies suggest inhibiting SPINK6 or EGFR could help treat nasopharyngeal carcinoma (NPC). In patients, high SPINK6 expression in tumors correlated with a high rate of metastasis...

Although the epidermal growth factor receptor is overexpressed in prostate cancer, efforts to repurpose inhibitors that are marketed for other solid tumors have met with little success. Now, researchers at the University of Michigan Medical...

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Prostate cancer Serine peptidase inhibitor Kazal type 1 (SPINK1); epidermal growth factor receptor (EGFR) Studies in mice suggest that inhibiting SPINK1...