BioCentury | Jul 12, 2018
Translation in Brief

New Therapeutic Targets and Biomarkers: June 2018

New Therapeutic Targets and Biomarkers: June 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during June 2018. Therapeutic targets are defined as any protein, gene or other...
BioCentury | Jun 20, 2018
Distillery Techniques

Biomarkers

TECHNOLOGY: Tissue markers Low esophageal levels of SPINK7 could help diagnose eosinophilic esophagitis. In esophageal tissue samples, SPINK7 protein and mRNA levels were lower in patients with eosinophilic esophagitis than in healthy volunteers, and the...
BioCentury | Apr 13, 2018
Targets & Mechanisms

Meeting the burden

A major theme at this year’s AACR is the abundance of preclinical discovery driven by molecular signatures in patient samples, suggesting the research community is heeding the call for studies better grounded in human data,...
BioCentury | Oct 27, 2016
Distillery Therapeutics

Cancer

INDICATION: Nasopharyngeal cancer Patient sample, cell culture and mouse studies suggest inhibiting SPINK6 or EGFR could help treat nasopharyngeal carcinoma (NPC). In patients, high SPINK6 expression in tumors correlated with a high rate of metastasis...
BioCentury | Mar 13, 2014
Distillery Techniques

Technology: Disease models

...mutations in serine peptidase inhibitor Kazal type 5 (SPINK5; LEKT1), an inhibitor of KLK5. The transgenic mice survived longer than Spink5-deficient...
BioCentury | Mar 31, 2011
Cover Story

Personalizing the prostate

Although the epidermal growth factor receptor is overexpressed in prostate cancer, efforts to repurpose inhibitors that are marketed for other solid tumors have met with little success. Now, researchers at the University of Michigan Medical...
BioCentury | Mar 17, 2011
Distillery Therapeutics

Indication: Cancer

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Prostate cancer Serine peptidase inhibitor Kazal type 1 (SPINK1); epidermal growth factor receptor (EGFR) Studies in mice suggest that inhibiting SPINK1...
BioCentury | Feb 6, 2006
Product Development

Breathless opportunities

...A number of asthma genes or gene complexes have now been identified. DPP10, GPRA and SPINK5...
...attack cytokines. GPRA encodes a GPCR that is up-regulated in epithelial cells in inflamed airways. SPINK5...
BioCentury | Oct 22, 2001
Company News

Oxagen, Oxford University deal

...asthma, psoriasis, inflammatory bowel disease and autoimmune thyroid disease. One patent, Oxagen said, covers the SPINK5...
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