00:27 , Mar 8, 2019 |  BC Innovations  |  Targets & Mechanisms

Flipping the switch in immuno-oncology

Tumor myeloid cells are emerging as prime candidates for filling a hole in the immuno-oncology tool box, offering targets that can simultaneously release the brakes and rev up the gas in the immune system. As...
08:00 , Jan 28, 2016 |  BC Innovations  |  Product R&D

Hitchhiker's guide to the gut

Applied Molecular Transport LLC (AMT) believes it has cracked the problem of orally delivering therapeutic proteins that has been the bane of biologics from the outset. The company has co-opted a strategy and a molecule...
08:00 , Mar 5, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: CD36 (GPIV); macrophage scavenger receptor 1 (MSR-1; SR-A; CD204)

Cardiovascular disease INDICATION: Atherosclerosis In vitro and mouse studies suggest sugar-based amphiphilic nanoparticles could help treat atherosclerosis. Macrophage recruitment and oxidized low-density lipoprotein (LDL) uptake via scavenger receptors such as CD36 and MSR-1 contributes to...
08:00 , Feb 6, 2014 |  BC Innovations  |  Targets & Mechanisms

Negative nanoparticles

A simple experimental error has opened up the potential for nanoparticles to treat disease rather than be used only as payloads. By accidentally using negatively charged nanoparticles instead of neutral ones, a team from Northwestern...
08:00 , Feb 14, 2008 |  BC Innovations  |  Targets & Mechanisms

Cancerous RAGE

Mounting evidence has linked chronic inflammation and cancer, but the sheer number of pathways and molecules that could be involved has slowed the identification of the molecular mechanisms that may lead inflamed tissue to become...
07:00 , Aug 26, 1996 |  BC Week In Review  |  Company News

Columbia University other research news

University researchers published in Nature their identification of the class A scavenger receptor (SR), found on microglia cells in the brain, as a possible therapeutic target in Alzheimer's. The receptor contains a collagen-like region that...