08:00 , Feb 10, 2011 |  BC Innovations  |  Distillery Therapeutics

Indication: Neurology

Indication Target/marker/pathway Summary Licensing status Publication and contact information Neurology Stroke Scavenger receptor class B member 3 (SCARB3); brain-derived neurotrophic factor (BDNF) Studies in mice suggest that inhibiting SCARB3 could help promote recovery in stroke...
07:00 , Aug 6, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Cardiovascular disease

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cardiovascular disease Atherosclerosis Nuclear receptor subfamily 2 group C member 2 (NR2C2; TR4); scavenger receptor class B member 3 (SCARB3; CD36) Studies in ex vivo murine...
08:00 , Nov 6, 2008 |  BC Innovations  |  Distillery Therapeutics

Indication: Endocrine disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Endocrine disease Obesity CD36 molecule (thrombospondin receptor) (SCARB3; FAT; CD36) A study in mice suggests that intestinal SCARB3 could be targeted to...
08:00 , Nov 6, 2008 |  BC Innovations  |  Targets & Mechanisms

The long and short of fat

With patent protection for Roche 's Xenical orlistat set to expire in 2009, the obesity drug's $531 million in 2007 sales will soon be up for grabs. Now, two mouse studies make a case for...
08:00 , Nov 6, 2008 |  BC Innovations  |  Targets & Mechanisms

The long and short of fat

With patent protection for Roche 's Xenical orlistat set to expire in 2009, the obesity drug's $531 million in 2007 sales will soon be up for grabs. Now, two mouse studies make a case for...
08:00 , Feb 7, 2008 |  BC Innovations  |  Targets & Mechanisms

Unraveling Bv8

Researchers at Genentech Inc. have added three big pieces to the puzzle of how prokineticin 2 ( PROK2 ; Bv8 ), a cytokine secreted by myeloid cells in the bone marrow, regulates tumor-related angiogenesis. The...
23:55 , Aug 31, 2007 |  BC Extra  |  Clinical News

Platelet receptor linked to atherosclerotic phenotype

Researchers from the Cleveland Clinic Foundation and colleagues reported in Nature Medicine that scavenger receptor class B member 3 ( SCARB3 , CD36 ) contributes to serum lipid abnormalities characteristic of atherosclerosis. In particular, knockout...