BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

...tumors. Other emerging metabolic targets include the lipid biosynthesis regulator ACLY, the nucleotide depleting enzyme SAMHD1...
...B7-H1; CD274) - Programmed cell death 1 ligand 1 PRDX4 - Peroxiredoxin 4 SAMHD1 - SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1...
BioCentury | Jan 19, 2017
Distillery Therapeutics

Cancer

...studies suggest combining cytarabine with SAMHD1 inhibition could help treat AML. In patients, levels of SAMHD1...
...measures of systemic AML and increased survival. Next steps could include identifying SAMHD1 inhibitors. TARGET/MARKER/PATHWAY: SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1)...
...CONTACT: Torsten Schaller, University Hospital Heidelberg, Heidelberg, Germany email: torsten.schaller@med.uni-heidelberg.de Hongjiang Li Heidelberg University Hospital Karolinska Institute Karolinska University Hospital SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1)...
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