BioCentury | May 21, 2020
Finance

HotSpot heads for clinic with $65M series B round to develop allosteric modulators

...S6K1 (RPS6KB1) - Ribosomal protein S6 kinase 70kDa polypeptide 1 Paul Bonanos, Associate Editor HotSpot Therapeutics Inc. Ribosomal protein S6 kinase...
BioCentury | Nov 21, 2019
Financial News

Nov. 20 Financial Quick Takes: Diagnostics play Lucence raises series A; plus Novo-Broad, PMV, Phoenix, Winterlight and BMS-Celgene

...its first clinical candidate, PMD-026, to treat triple-negative breast cancer. The therapy targets ribosomal protein S6 kinase...
BioCentury | Aug 23, 2019
Company News

HotSpot acquires Macroceutics for focused allosteric library

...and S6K for non-alcoholic steatohepatitis (NASH) and diabetes. Targets: PRKCQ - Protein kinase C θ; S6K...
...for non-alcoholic steatohepatitis (NASH) and diabetes. Targets: PRKCQ - Protein kinase C θ; S6K - S6 kinase Allison...
BioCentury | Jun 20, 2019
Targets & Mechanisms

Moving beyond the active site: why allostery is newly in fashion

...Preclinical HotSpot Therapeutics Inc. Protein kinase C θ (PRKCQ) Autoimmune, graft-versus-host disease (GvHD) Preclinical S6 kinase (S6K...
BioCentury | Feb 22, 2019
Targets & Mechanisms

Expansion into TNBC

...oncogene homolog OTULIN - OTU deubiquitinase with linear linkage specificity RSK2 (RPS6KA3) - Ribosomal protein S6 kinase...
BioCentury | Feb 8, 2019
Product R&D

Reducing R(i)SK in TNBC

...Designs MAPK (ERK) - MAP kinase; PDK - pyruvate dehydrogenase kinase; RSK2 - Ribosomal protein S6 kinase...
...cell death 1 ligand 1 PDK - Pyruvate dehydrogenase kinase RSK2 (RPS6KA3) - Ribosomal protein S6 kinase...
...3 YBX1 (YB1) - Y box binding protein 1 Stephen Hansen, Associate Editor Phoenix Molecular Designs Roche Ribosomal protein S6 kinase...
BioCentury | Jan 18, 2019
Company News

Phoenix, Roche partner to develop TNBC biomarker

...ligand 1; RPS6KA3 (RSK2) - Ribosomal protein S6 kinase 90kDa polypeptide 3; RSK - Ribosomal protein S6 kinase...
...B.C. Roche (SIX:ROG; OTCQX:RHHBY), Basel, Switzerland Business: Diagnostic Stephen Hansen PMD026 Phoenix Molecular Designs Roche Ribosomal protein S6 kinase (RSK) Ribosomal protein S6 kinase...
BioCentury | Jan 17, 2019
Company News

Phoenix, Roche partner to develop TNBC biomarker

...ligand 1; RPS6KA3 (RSK2) - Ribosomal protein S6 kinase 90kDa polypeptide 3; RSK - Ribosomal protein S6 kinase Stephen...
BioCentury | Jul 20, 2018
Financial News

Hotspot debuts with $45M to find, drug natural allosteric sites

...design and cellular assays. The company's two lead programs are allosteric inhibitors of ribosomal protein S6 kinase...
...board. HotSpot Therapeutics Inc., Cambridge, Mass. Karen Tkach Tuzman HotSpot Therapeutics Protein kinase C (PKC) theta (PRKCQ) Ribosomal protein S6 kinase...
BioCentury | Jul 17, 2018
Financial News

HotSpot debuts with $45M to find, drug natural allosteric sites

...design and cellular assays. The company's two lead programs are allosteric inhibitors of ribosomal protein S6 kinase...
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