BioCentury | Oct 25, 2019
Product Development

Lykera takes aim at aggressive cancers by targeting pre-metastatic niche

...is currently developing S100-targeting therapies in cancer and inflammation. Active Biotech has small molecules targeting S100A9...
...A7 S100A8 (calgranulin A; MRP8) - S100 calcium binding protein A8 S100A9 (calgranulin B; MRP14) - S100 calcium binding protein A9...
...A4 (S100A4) Tumor necrosis factor (TNF) S100 calcium binding protein A8 (S100A8) (calgranulin A) (MRP8) S100 calcium binding protein A9 (S100A9) (calgranulin B) (MRP14) Programmed...
BioCentury | Sep 10, 2019
Distillery Therapeutics

S100A9 could normalize metabolic imbalances from insulin deficiency

...DISEASE CATEGORY: Endocrine/metabolic INDICATION: Diabetes Promoting expression of S100A9, a plasma protein induced by leptin, could...
...from 16.5 and 34 days to 34.5 and 80 days, respectively. TARGET/MARKER/PATHWAY: S100 calcium binding protein A9 (S100A9; calgranulin B; MRP14...
...giorgio.ramadori@unige.ch CONTACT: Roberto Coppari, same affiliation as above email: roberto.coppari@unige.ch Claire Quang University of Geneva S100 calcium binding protein A9 (S100A9) (calgranulin B) (MRP14) Diabetes...
BioCentury | Aug 10, 2018
Clinical News

Active, Teva's laquinimod misses in Phase II for HD

...NYSE:TEVA; Tel Aviv:TEVA), Petah Tikva, Israel Product: Laquinimod Business: Neurology Molecular target: S100 calcium binding protein A9 (S100A9; calgranulin B; MRP14...
...Brand), 5062 (Compound #), laquinimod (Generic), SAIK-MS (Informal) Active Biotech AB Teva Pharmaceutical Industries Ltd. S100 calcium binding protein A9 (S100A9) (calgranulin B) (MRP14) Huntington's...
BioCentury | Dec 8, 2017
Clinical News

Active, Teva's laquinimod misses in Phase II for PPMS

...Tel Aviv:TEVA), Petah Tikva, Israel Product: Laquinimod (SAIK-MS) Business: Autoimmune Molecular target: S100 calcium binding protein A9 (S100A9; calgranulin B; MRP14...
...Status: Phase II data Milestone: NA Jaime De Leon laquinimod Nerventra SAIK-MS Active Biotech AB Teva Pharmaceutical Industries Ltd. S100 calcium binding protein A9 (S100A9) (calgranulin B) (MRP14...
BioCentury | Jun 7, 2017
Distillery Therapeutics

Cardiovascular; hematology

...knockout of S100A9 decreased reticulated platelet numbers in the blood compared with vehicle or normal S100A9...
...for multiple cancers and preclinical testing to treat multiple myeloma (MM). TARGET/MARKER/PATHWAY: S100 calcium binding protein A9 (S100A9; calgranulin B; MRP14...
...Ala. email: pnreddy@uab.edu Hongjiang Li Baker IDI Heart and Diabetes Institute University of Alabama at Birmingham S100 calcium binding protein A9 (S100A9) (calgranulin B) (MRP14...
BioCentury | May 12, 2017
Clinical News

Teva's laquinimod fails Phase III RRMS trial

...Israel Product: Laquinimod ( SAIK-MS ) Business: Autoimmune Molecular target: S100 calcium binding protein A9 ( S100A9 ; calgranulin B; MRP14...
...Status: Phase III data Milestone: NA Jaime De Leon laquinimod SAIK-MS Active Biotech AB Teva Pharmaceutical Industries Ltd. S100 calcium binding protein A9 (S100A9) (calgranulin B) (MRP14...
BioCentury | Mar 29, 2017
Distillery Techniques

Biomarkers

...binding protein A8 ( S100A8 ; calgranulin A ; MRP8) and S100A9 ( calgranulin B ; MRP14...
...protein (LGALS3BP) Matrix metalloproteinase 9 (MMP9) S100 calcium binding protein A8 (S100A8) (calgranulin A) (MRP8) S100 calcium binding protein A9 (S100A9) (calgranulin B) (MRP14...
BioCentury | Feb 1, 2016
Clinical News

Laquinimod: Phase II amended

...Petah Tikva, Israel Product: Laquinimod ( SAIK-MS ) Business: Neurology Molecular target: S100 calcium binding protein A9 (S100A9) (calgranulin B) (MRP14...
BioCentury | Jan 11, 2016
Clinical News

Laquinimod: Phase II amended

...Petah Tikva, Israel Product: Laquinimod ( SAIK-MS ) Business: Autoimmune Molecular target: S100 calcium binding protein A9 (S100A9) (calgranulin B) (MRP14...
BioCentury | Jan 11, 2016
Clinical News

Laquinimod: Phase III amended

...Petah Tikva, Israel Product: Laquinimod ( SAIK-MS ) Business: Autoimmune Molecular target: S100 calcium binding protein A9 (S100A9) (calgranulin B) (MRP14...
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