BioCentury | Sep 19, 2019
Distillery Therapeutics

S100A10 and SP1 identified as ALS targets

...lateral sclerosis (ALS) Inhibiting the adaptor protein S100A10 or SP1, a transcription factor that controls S100A10...
...expression, could treat ALS and injury-induced motor neuron degeneration. In mice with ALS, siRNA against S100A10...
...discontinued marketing of Mithracin for cancer in 2000. TARGET/MARKER/PATHWAY: Sp1 transcription factor (SP1); S100 calcium binding protein A10 (S100A10; P11...
BioCentury | Oct 5, 2017
Translation in Brief

SSRIs' first responders

...Rockefeller team led by Paul Greengard showed in normal mice that S100 calcium binding protein A10 ( S100A10 ; p11...
...S100A10 ; p11) was highly enriched in CCK-expressing neurons, and that in cell-based assays S100A10...
...the team's findings. Egeland, M., et al. "Neurogenic effects of fluoxetine are attenuated in p11 (S100A10...
BioCentury | Aug 3, 2017
Translation in Brief

New Therapeutic Targets and Biomarkers: July 2017

...326 (ZNF326; ZIRD) Lung cancer S100 calcium binding protein A11 (S100A11) Tumor levels of S100A11, S100A10...
BioCentury | Jul 18, 2017
Distillery Techniques

Biomarkers

...TECHNOLOGY: Tissue markers Tumor levels of S100A10 , S100A11 and TNC mRNAs could help predict survival...
...could help predict survival in lung cancer. In 57 lung adenocarcinoma patients, mRNA levels of S100A10...
...findings in a larger cohort of lung cancer patients. DESCRIPTION: mRNA levels of S100 calcium binding protein A10 (S100A10; P11...
BioCentury | Feb 28, 2017
Distillery Techniques

Biomarkers

...from patients, S100A10 levels were lower than in cytotoxic T cells from healthy volunteers, and S100A10...
...a larger cohort of PD patients and healthy volunteers. DESCRIPTION: Leukocyte levels of S100 calcium binding protein A10 (S100A10; P11...
...Per.Svenningsson@ki.se CONTACT: Paul Greengard, The Rockefeller University, New York, N.Y. email: greengard@mail.rockefeller.edu Lauren Martz Karolinska Institute The Rockefeller University S100 calcium binding protein A10 (S100A10) (P11) Parkinson's...
BioCentury | Mar 7, 2013
Distillery Therapeutics

Indication: Neurology

...and contact information Neurology Depression Annexin A2 (ANXA2); helicase-like transcription factor (HLTF; SMARCA3); S100 calcium binding protein A10 (S100A10; P11...
...series of in vitro and mouse studies identified SMARCA3 as a binding partner of the P11-ANXA2...
...than those seen in wild-type controls. Next steps include identifying the genes targeted by the P11-ANXA2...
BioCentury | Nov 11, 2010
Distillery Therapeutics

Indication: Neurology

...status Publication and contact information Neurology Depression S100 calcium binding protein A10 (S100A10; P11) Mouse studies suggest that restoring P11...
...to those seen with total p11 knockout. In p11 knockout mice, AAV vector-mediated restoration of p11...
...brain tissues, depressed patients had lower P11 levels than healthy controls. Next steps include studying p11...
BioCentury | Nov 4, 2010
Targets & Mechanisms

Depression paths of least resistance

...colleagues at the Karolinska Institute . The team previously reported that P11 ( S100 calcium binding protein A10 ; S100A10...
...was to increase P11 levels in the nucleus accumbens of the brain by delivering the P11...
...p11 small hairpin RNA to the nucleus accumbens of wild-type mice. Indeed, shRNA-mediated knockdown of p11...
BioCentury | Feb 21, 2008
Distillery Therapeutics

This Week in Therapeutics

...mice and rats with lesions increased levels of the 5-HT1B receptor and its adaptor protein p11...
...treated with the 5-HT1B receptor agonist CP9423 showed reduced l-DOPA-induced behavioral side effects compared with p11...
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