BioCentury | Aug 9, 2018
Translation in Brief

Identifying the ubiquitinators

...p53 binding protein homolog (MDM2; HDM2), itchy E3 ubiquitin protein ligase (ITCH) and ring finger protein 31 (RNF31; HOIP...
...if they could inhibit E3 ligase activity. Screening of 1,430 drugs against MDM2, ITCH and RNF31...
...to toxicity. Trost said his group plans to use the platform to identify inhibitors of RNF31. Mary...
BioCentury | Aug 1, 2018
Distillery Techniques

Assays and screens

...p53 binding protein homolog (MDM2; HDM2), itchy E3 ubiquitin protein ligase (ITCH) and ring finger protein 31 (RNF31; HOIP...
...interactive E2/E3 enzymes. In another proof-of-concept experiment, screening of 1,430 drugs against MDM2, ITCH and RNF31...
...the three enzymes by over 50%. Next steps include using the assay to identify additional RNF31...
BioCentury | Apr 25, 2018
Translation in Brief

Prostate prognosis

...helicase 30 (DHX30), PHD finger 15 (PHF15; JADE2), N-deacetylase and N-sulfotransferase 2 (NDST2), ring finger protein 31 (RNF31; HOIP...
BioCentury | May 8, 2014
Distillery Therapeutics

Indication: Cancer

...information Cancer Cancer Ring finger protein 31 (RNF31; HOIP) Cell culture studies suggest inhibiting the E3 ubiquitin ligase HOIP...
...platinum-based chemotherapeutics such as cisplatin. In an siRNA screen using a human osteosarcoma cell line, HOIP...
...against HOIP increased sensitivity to cisplatin compared with control siRNA. Next steps include determining whether HOIP...
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