03:28 , Jan 19, 2018 |  BC Innovations  |  Tools & Techniques

Synthetic expressions

Bringing synthetic biology to transcriptional regulation could catalyze a new generation of gene therapies that are more tunable, disease-specific and easy to deliver than the products dominating the field. The new constructs include synthetic promoters...
19:13 , Aug 18, 2017 |  BC Extra  |  Preclinical News

Researchers identify 21 new cancer targets

In a paper published in Science , researchers at KTH-Royal Institute of Technology and three Swedish institutes analyzed the transcriptome of 17 major cancer types and identified 32 potential targets that could be inhibited to...
07:00 , May 7, 2015 |  BC Innovations  |  Distillery Therapeutics

Therapeutics: Viral RNA polymerase PA subunit; viral RNA polymerase PB1 subunit

Infectious disease INDICATION: Influenza virus In vitro studies suggest inhibitors of interactions between influenza viral RNA polymerase PA and PB1 subunits could help treat influenza infection. Chemical synthesis and in vitro testing of triazolopyrimidine analogs...
07:00 , May 21, 2009 |  BC Innovations  |  Distillery Therapeutics

Indication: Infectious disease

This week in therapeutics Indication Target/marker/pathway Summary Licensing status Publication and contact information Infectious disease HCV HCV NS5B polymerase Studies in vitro and in rats identified inhibitors of HCV NS5B RNA-dependent RNA polymerase that could...
08:00 , Nov 6, 2006 |  BioCentury  |  Regulation

Nuc-ing HCV

One of the few positives to emerge from the HIV epidemic was the amount of research dedicated to uncovering the inner workings of infectious diseases. Indeed, just as small molecule drugs targeting viral enzymes have...
07:00 , Sep 27, 2004 |  BioCentury  |  Tools & Techniques

Building on safe ground

Since the advent of technologies to generate antibodies in the lab in 1975, a great many companies have been founded on the premise that these platforms could easily be used to crank out treatments for...