BioCentury | Mar 29, 2019
Targets & Mechanisms

Next-wave targets at AACR 2019 start filling the blanks in the tumor microenvironment

...progression in esophageal cancer, and inhibiting PCDHB9 could help block esophageal cancer metastasis. Hiroshima University RIO kinase 2 (RIOK2)...
BioCentury | Oct 4, 2017
Preclinical News

Team ties target to GBM progression, identifies biomarker

In a paper published in Cancer Cell , researchers at Massachusetts Institute of Technology and Harvard Medical School used an in vivo short hairpin RNA screen to identify an epigenetic regulator, protein arginine methyltransferase 5 (PRMT5)...
BioCentury | Apr 21, 2016
Distillery Therapeutics

Therapeutics: Methionine adenosyltransferase 2A (MAT2A); protein arginine methyltransferase 5 (PRMT5); RIO kinase 1 (RIOK1); methylthioadenosine phosphorylase (

Cancer INDICATION: Colorectal cancer Cell culture and mouse studies suggest inhibiting the MAT2A / PRMT5 / RIOK1 axis could help treat MTAP-deficient colon cancer. In a human MTAP-deficient colon cancer cell line, shRNA targeting MAT2A,...
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