23:28 , Jun 7, 2018 |  BC Innovations  |  Translation in Brief

New Therapeutic Targets and Biomarkers: May 2018

New Therapeutic Targets and Biomarkers: May 2018 Select top therapeutic targets and biomarkers covered by BioCentury or added to the BCIQ database during May 2018. Therapeutic targets are defined as any protein, gene or other...
17:51 , May 16, 2018 |  BC Innovations  |  Distillery Therapeutics

Pulmonary

INDICATION: Cystic fibrosis (CF) Cell culture studies identified a phenylbenzimidamide-based RNF5 inhibitor that could help treat CF in patients harboring the ΔF508 loss-of-function mutation in CFTR. In silico screening of a small molecule library for...
22:15 , May 11, 2018 |  BC Extra  |  Preclinical News

Inhibiting the ubiquitin ligase RNF5 to treat CF

In a paper published in Cell Chemical Biology , Italian researchers identified a pharmacological inhibitor of ring finger protein 5 (RNF5) that prevented the premature degradation of mutant F508del cystic fibrosis transmembrane conductance regulator (CFTR)...