BC Innovations | Dec 20, 2016
Distillery Therapeutics

Cancer

INDICATION: Pancreatic cancer; colorectal cancer Cell culture, mouse and patient sample studies suggest anti- FZD5 mAbs could help treat pancreatic, colorectal, and other RNF43 -mutant cancers. In four RNF43-mutant human pancreatic ductal adenocarcinoma (PDAC) cell...
BC Innovations | Jun 25, 2015
Distillery Therapeutics

Therapeutics: Ring finger protein 43 (RNF43); zinc and ring finger 3 (ZNRF3)

Cancer INDICATION: Cancer Cell culture and mouse studies suggest WNT pathway inhibitors could help treat gastrointestinal, colonic and other cancers that harbor mutations in RNF43 and ZNRF3 . Organoids cultured from RNF43/ZNRF3 double-knockout mouse epithelial intestinal...
BC Innovations | May 31, 2012
Distillery Therapeutics

Indication: Cancer

Indication Target/marker/pathway Summary Licensing status Publication and contact information Cancer Pancreatic cancer Zinc and ring finger 3 (ZNRF3); ring finger protein 43 (RNF43) An in vitro study identified two new components of the wingless-type MMTV...
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