BioCentury | Feb 28, 2019
Distillery Therapeutics

Infectious disease

...Escherichia; Gram-negative bacterial infection Cell culture and mouse studies identified a deoxystreptamine-based inhibitor of the ribosomal 30S subunit...
...of the model bacteria Thermus thermophilus showed the compound bound the decoding region of the ribosomal 30S subunit...
...steps could include testing the compound in mouse models of other Gram-negative bacterial infections. TARGET/MARKER/PATHWAY: Ribosomal 30S subunit...
BioCentury | Aug 10, 2018
Clinical News

FDA panel backs Insmed lung infection compound in narrow population

...liposome inhalation suspension) Business: Infectious Chris Lieu Arikayce, amikacin (alis, amikacin liposome inhalation suspension, arikace, slit amikacin) Insmed Inc. Ribosomal 30S subunit Mycobacterium...
BioCentury | Aug 7, 2018
Company News

FDA panel backs Insmed lung infection compound in narrow population

...Insmed were halted on Tuesday. Chris Lieu Arikayce, amikacin (alis, amikacin liposome inhalation suspension, arikace, slit amikacin) Insmed Inc. Ribosomal 30S subunit Mycobacterium...
BioCentury | Apr 17, 2018
Distillery Therapeutics

Infectious disease

...INDICATION: Bacterial infection; sepsis Cell culture and mouse studies identified an odilorhabdin-based bacterial ribosomal 30S subunit inhibitor that...
...4-16 µg/mL, and crystallographic analysis showed the compound bound the decoding center of the bacterial ribosomal 30S subunit...
...Nosopharm S.A.S. has NOSO-502, an odilorhabdin antibiotic, in preclinical testing to treat bacterial infection. TARGET/MARKER/PATHWAY: Ribosomal 30S subunit...
BioCentury | Jan 5, 2018
Clinical News

Paratek begins rolling NDA of omadacycline for ABSSSIs and CABP

...NASDAQ:ZLAB), Shanghai, China Product: Omadacycline (ZL-2401) (formerly PTK 0796) Business: Infectious Chris Lieu omadacycline ZL-2401 Paratek Pharmaceuticals Inc. Zai Lab Ltd. Ribosomal 30S subunit...
BioCentury | Dec 8, 2017
Clinical News

Bayer's Amikacin Inhale misses in Phase III for Gram-negative pneumonia

...Calif. Bayer AG (Xetra:BAYN), Leverkusen, Germany Product: Amikacin Inhale (BAY41-6551, NKTR-061) Business: Infectious Molecular target: Ribosomal 30S subunit...
...ICU) days up to day 28-32 Status: Phase III data Milestone: NA Chris Lieu Amikacin Inhale BAY41-6551 NKTR-061 Bayer AG Nektar Therapeutics Ribosomal 30S subunit...
BioCentury | Oct 10, 2017
Distillery Therapeutics

Cancer

...INDICATION: Chronic myelogenous leukemia (CML) Patient sample, cell culture and mouse studies suggest combining ribosomal 30S subunit inhibitors...
...respiration were higher than in HSCs from healthy volunteers. In the primary leukemic HSCs, the ribosomal 30S subunit...
...structure infection (SSSI), and has the compound in Phase III testing for dermal ulcers. TARGET/MARKER/PATHWAY: Ribosomal 30S subunit...
BioCentury | Sep 8, 2017
Clinical News

Insmed's ALIS meets in Phase III for rare lung infection

...Bridgewater, N.J. Product: ALIS ( amikacin liposome inhalation suspension , Arikayce) Business: Infectious Molecular target: Ribosomal 30S subunit...
...6-minute walk distance (6MWD) Status: Phase III data Milestone: NA Jaime De Leon ALIS amikacin liposome inhalation suspension Arikace Arikayce Insmed Inc. Ribosomal 30S subunit...
BioCentury | Sep 5, 2017
Clinical News

Insmed jumps on Phase III success in rare lung infection

...BioCentury Extra, Oct. 5, 2016) . Jaime De Leon ALIS amikacin amikacin liposome inhalation suspension Arikace Arikayce INS1007 Insmed Inc. AstraZeneca plc Dipeptidyl peptidase-1 (DPP-1) (CTSC) Ribosomal 30S subunit...
BioCentury | Jul 21, 2017
Clinical News

Paratek planning regulatory submissions for omadacycline antibiotic

...Zai Lab Ltd. , Shanghai, China Product: Omadacycline (formerly PTK 0796) Business: Infectious Molecular target: Ribosomal 30S subunit...
...Status: Phase III data Milestone: Submit NDA (1Q18); submit MAA (2018) Alicia Parker omadacycline Paratek Pharmaceuticals Inc. Zai Lab Ltd. Ribosomal 30S subunit...
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