BioCentury | Nov 30, 2018
Targets & Mechanisms

Revving up metabolism at ASH 2018

...CEBPA) 63 Peroxisome proliferation activated receptor γ coactivator 1-α (PGC-1α; PPARGC1A) 5 Nucleic acid synthesis Ribonucleotide reductase...
BioCentury | Jul 31, 2017
Distillery Therapeutics

Cancer

...221 and 442 nM, respectively. Next steps include additional preclinical studies of the compound. TARGET/MARKER/PATHWAY: Ribonucleotide reductase...
...CONTACT: Chris Godfrey Dealwis, Case Western Reserve University, Cleveland, Ohio email: cxd114@case.edu Claire Quang Case Western Reserve University Ribonucleotide reductase Ribonucleotide reductase...
BioCentury | Jul 11, 2016
Clinical News

COH29: Phase I started

...of Hope , Duarte, Calif. Product: COH29 Business: Cancer Molecular target: Ribonucleotide reductase Description: Small molecule ribonucleotide reductase...
...which no standard therapy exists Endpoint: Maximum tolerated dose (MTD); changes in plasma biomarker expression, ribonucleotide reductase...
BioCentury | Mar 21, 2016
Emerging Company Profile

Targeting toxicity

...ribonucleotide reductase inhibitor that is slated to enter Phase I testing this year in solid tumors. Ribonucleotide reductase...
...hydroxyurea and gemcitabine do. The molecule interferes with the interaction between ribonucleotide reductase's protein subunits - ribonucleotide reductase...
...Calif. University of California Irvine, Irvine Calif. References Zhou, B., et al. "A small-molecule blocking ribonucleotide reductase...
BioCentury | Aug 24, 2015
Company News

City of Hope, Novonco Therapeutics deal

...City of Hope granted Novonco exclusive rights to COH29 . The small molecule ribonucleotide reductase inhibitor is...
BioCentury | Jul 23, 2015
Distillery Therapeutics

Therapeutics: Ribonucleotide reductase M1 (RRM1; R1); ribonucleotide reductase M2 (RRM2; R2)

...heart failure, intracoronary infusion of an adeno-associated virus (AAV) serotype 6 (AAV6) vector encoding the ribonucleotide reductase...
...include conducting a larger preclinical study with human-grade delivery vectors. TARGET/MARKER/PATHWAY: Ribonucleotide reductase M1 (RRM1; R1); ribonucleotide reductase...
BioCentury | Feb 19, 2015
Distillery Therapeutics

Therapeutics: Ribonucleotide reductase M1 (RRM1; R1); ribonucleotide reductase M2 (RRM2; R2)

...the concept in humans. (See "Ace of Hearts," page 5) TARGET/MARKER/PATHWAY: Ribonucleotide reductase M1 (RRM1; R1); ribonucleotide reductase...
BioCentury | Feb 19, 2015
Targets & Mechanisms

Ace of hearts

...AAV) vectors to deliver mouse RRM1 and RRM2 , two subunits of the dATP-synthesizing enzyme ribonucleotide reductase...
...endopeptidase ( neprilysin ) RLN2 (H2) - relaxin 2 RRM1 - Ribonucleotide reductase M1 RRM2 - Ribonucleotide reductase...
BioCentury | Feb 13, 2015
Targets & Mechanisms

Ace of hearts

...AAV) vectors to deliver mouse RRM1 and RRM2 , two subunits of the dATP-synthesizing enzyme ribonucleotide reductase...
...endopeptidase ( neprilysin ) RLN2 (H2) - relaxin 2 RRM1 - Ribonucleotide reductase M1 RRM2 - Ribonucleotide reductase...
BioCentury | Jul 24, 2014
Cover Story

It is an RNA world

...Therapeutics Inc. (TSX:LOR; Pink:LRUSF) Antisense inhibitor of ribonucleotide reductase...
...by ProNAi CALAA-01, an siRNA drug targeting ribonucleotide reductase...
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